司替戊醇多少钱一盒?在哪里购买?

Stipentol is a drug used to treat certain epilepsy syndromes, especially in patients who take it in combination with clobazam. Currently, there are mainly French Biocodex and German versions of original drugs on the market, and the prices vary depending on specifications and versions. This article will introduce in detail the price, purchase channels and pharmacokinetic properties of stiripentol to help patients and their families better understand this drug.

How much does a box of stiripentol cost?

The price varies depending on the version and specification. The following is the specific price information of the French Biocodex and the German version of the original drug.

Prices of original drugs produced by Biocodex in France

The original drugs produced by Biocodex in France are available in two specifications: the price of 250mg*60 capsules/box is approximately US$384 per box, and the price of 500mg*60 capsules/box is approximately US$617.

The price of the German version of the original drug

The price of the German version of the original drug is slightly higher than the French version. The price of 250mg*60 bags/box is about US$453, and the price of 500mg*60 bags/box is about US$823. The German version of the drug uses a pouch design on the packaging to make it convenient for patients to use.

Factors affecting price

The price of stiripentol is affected by many factors, including production costs, transportation costs, and market supply and demand. Patients should make a reasonable choice based on their own needs and financial capabilities.

Understanding the price information of stiripentol can help patients and families make more informed decisions when purchasing.

Where to buy stiripentol

Stipentol has not yet been launched in China, but patients can still purchase the drug through formal channels. The following are some common ways to purchase it.

Purchased in regular hospitals

Patients can purchase stiripentol through the pharmacies of regular hospitals. Hospital pharmacies can usually provide quality-assured medicines, but attention should be paid to the production date and authenticity of the medicines.

Overseas medical service institutions

Since stiripentol is not available in China, some patients choose to purchase it through overseas medical service institutions. There are certain risks in this method, and patients should carefully choose reliable medical institutions to avoid being deceived.

Purchasing generic drugs

There are generic drugs produced by Laos Lucius and other companies on the market, and the prices are relatively low. Patients should pay special attention to the quality and source of the drugs when purchasing generic drugs.

No matter which channel they purchase, patients should ensure that the source of medicines is formal and avoid buying fake or substandard medicines.

Pharmacokinetics of stiripentol

The pharmacokinetic properties of stiripentol determine its absorption, distribution, metabolism and excretion processes in the body.

Absorption and Distribution

Stipentol is rapidly absorbed and reaches the peak blood level in about 1.5 hours. Its bioavailability is unknown, but it is well absorbed. The drug is extensively bound to plasma proteins, with a binding rate of approximately 99%.

Metabolism and Excretion

Stipentol is extensively metabolized in the body, mainly through demethylation and glucuronidation reactions. Metabolites are mainly excreted through the kidneys. About 73% of the administered dose is excreted in urine, and 13%-24% is excreted in feces in the form of original drug.

Clearment rate and half-life

The clearance rate of stiripentol decreases with increasing dose. The clearance rate is 40L/(kg·d) at a daily dose of 600 mg and decreases to 8L/(kg·d) at a daily dose of 2400 mg. The elimination half-life is 4.5-13 hours, extending with increasing dose.

Understanding the pharmacokinetic properties of stiripentol can help patients better understand its mechanism of action and usage.