喜保宁导致的不良反应怎么治疗

Vigabatrin, this drug is especially suitable for patients with refractory partial epilepsy who have poor response or intolerance to other anti-epileptic drugs. However, the use of Vigabatrin may cause a series of adverse reactions, which may seriously affect the patient's quality of life. In this article, we will mainly introduce the adverse reactions and treatment methods of this drug.

Vigabatrin'sAdverse Reaction Introduction

Visual field loss: The most common serious adverse reaction is visual field loss. Patients may experience concentric narrowing of the visual field in both eyes, especially the nasal visual field. This defect may be irreversible and may not appear until months or years after treatment. Visual field loss may seriously affect the patient's driving, reading, etc. daily life.

Central nervous system symptoms: drowsiness, insomnia, fatigue, and difficulty concentrating. These symptoms may be common early in treatment, but may gradually lessen or disappear over time. However, these symptoms can affect the patient's mental state and work efficiency and even lead to accidents.

Corresponding treatment methods for adverse reactions

Visual field defect: If the patient discovers visual field defect, it is recommended to undergo an eye examination immediately to confirm the diagnosis. If the visual field defect is found to be severe or continues to progress, you should promptly discuss with your doctor to consider gradually stopping Vigabatrin and choose other anti-epileptic drugs under the guidance of your doctor. Patients should also have regular visual field examinations to monitor changes in their condition. Visual field loss may be irreversible. We should try our best to avoid this situation. Prevention is a critical step. Monitor visual field changes regularly during treatment and a complete ophthalmic evaluation should be performed before starting treatment.

Central nervous system symptoms: For central nervous system symptoms such as drowsiness and insomnia, the drug dosage or medication time can be adjusted according to the patient's specific conditions. If symptoms are severe or persist, other drugs may be considered for symptomatic treatment. Patients should maintain adequate sleep and rest and avoid overexertion and mood swings to reduce central nervous system symptoms.

Auxiliary examination

Visual field examination: This is an important means to evaluate whether Vigabatrin treatment causes visual field defects. Commonly used examination methods include static visual field examination (such as Humphrey perimetry) and dynamic visual field examination (such as Goldmann perimetry). This examination can regularly monitor changes in the patient's visual field and promptly detect and treat visual field defects.

Ophthalmic examination: including fundus examination, intraocular pressure measurement, etc., to comprehensively evaluate the patient’s eye health. Interference from other eye diseases can be excluded to ensure that visual field defects are related to Vigabatrin treatment.

Blood tests: including liver and kidney function, routine blood tests and other routine tests to assess the patient’s overall health. Understand whether the patient has abnormal liver and kidney function and other factors that may affect drug metabolism and excretion to provide a basis for adjusting drug dosage.