苯巴那酯(cenobamate)用法用量是怎样的？有副作用吗？

Cenobamate is a new tetrazolidinyl carbamate derivative developed by SK Life Sciences. It has an inhibitory effect on sustained sodium ion currents and has broad-spectrum anticonvulsant activity, effectively inhibiting epilepsy in focal epilepsy models. (cenobamate) is a sodium channel blocker.

What is the dosage of cenobamate?

Cenobamate has been launched in the United States in 6 dosages: 12.5 mg, 25 mg, 50 mg, 100 mg, and 200 mg. Initial dose: Weeks 1 and 2: 12.5 mg once daily with or without food. Take with water and do not chew. Maintenance dose: 200 mg once daily at week 11 and thereafter. For patients with mild to moderate hepatic impairment (liver function assessment score 5-9), the maximum recommended dose is 200 mg once daily. Patients must follow the doctor's instructions and should not change or stop taking medications at will. It is contraindicated in patients allergic to cenobamate.

Does cenobamate have any side effects?

Phenobarate (cenobamate) has a very good inhibitory effect on epilepsy, but it also has side effects. Shortening of the QT interval on the electrocardiogram, suicidal behavior tendencies, eosinophilia and systemic symptoms (DRESS)/multiple organ hypersensitivity reactions, nervous system adverse reactions (insomnia, sedation, somnolence, fatigue, asthenia), etc. are relatively common side effects of phenobarate. At the same time, serious side effects may occur if the drug exceeds the recommended dose. It is recommended to pay attention to the patient's physical reaction during medication. If there is any intolerance, contact the doctor in time for symptomatic treatment.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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