第三代抗癫痫新药-卫克泰

Epilepsy is a common and complex neurological disease. It is a chronic disease caused by repeated epileptic seizures caused by highly synchronous discharge of nerves. There are approximately 50 million epilepsy patients worldwide. Among newly diagnosed epilepsy patients, about 70% can successfully control their epileptic seizures with one drug, but about 30% of patients are poorly treated with two or more anti-epileptic drugs (AEDs), resulting in refractory epilepsy. It was approved for marketing by the US FDA in 2012 and is currently mainly used for the treatment of partial seizures in epilepsy over 12 years of age and the add-on treatment of primary generalized tonic-clonic seizures. Vectai is a highly non-competitive antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, inhibiting synaptic transmission mediated by AMPA receptors and thereby reducing neuronal excitability.

Studies have shown that 4 mg/d, 8 mg/d and 12 mg/d of Vecta have a ≥50% reduction in seizure frequency significantly higher than that of placebo. 8 mg/d and 12 mg/d of Vecta have no significant difference in the complete seizure-free rate compared with placebo, but the withdrawal rate due to adverse reactions is higher than that of placebo. Our comprehensive analysis of all doses (2mg/d, 4mg/d, 8mg/d, 12mg/d) shows that the percentage reduction of seizure frequency by ≥50%, the complete seizure-free rate of epilepsy, and the withdrawal rate due to adverse reactions are all higher than those of placebo, while the rate of serious adverse reactions is not significantly different from placebo.

Found in studies: nausea, falls, headaches, fatigue, drowsiness, irritability, dizziness and more. Here is one thing that the editor would like to remind everyone. If you are currently using Wei Ketai, the patient must strictly follow the doctor's instructions. Irregular medication may lead to aggravation of the disease and side effects. Only by taking the medication on time and quantitatively according to the doctor's instructions can the effect of the drug itself be maximized.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.