是天使也是魔鬼！癫痫药物氯巴占的风波始末

"I just made a record and was not detained. I can still go home and take care of my children. The police at the police station also understood me very well and did not confiscate my medicine." Ms. Li walked out of the public security bureau tiredly, but at this time, she had the identity of a "criminal suspect". The "culprit" that caused all this was a drug called.

In the eyes of Li's mother, clobazam is a good drug that can save her child's life. In the eyes of the investigators, it is a controlled drug.

The reason why Clobazam has polarized evaluations from heaven to hell is because it has different approved uses at home and abroad. Overseas, Clobazam is a drug used to treat epilepsy and has been approved for marketing in many countries. In China, it is on the list of second-category psychotropic drugs controlled by the state.

Is Clobazam an angel or a devil?

When the news came out that Mrs. Li used clobazam to treat her child's epilepsy, but was considered to have purchased controlled drugs, it aroused discussions among netizens. Can clobazam really treat epilepsy? If so, why is it still considered a controlled drug?

If you want to know whether clobazam is effective for epilepsy, you must go back to the source and understand what kind of disease epilepsy is.

Epilepsy is what we often call epilepsy, or epilepsy. A chronic disease of brain dysfunction caused by abnormal discharge of brain nerves. According to statistics, there are approximately 9 million epilepsy patients in our country. The causes are complex and are generally related to genetics, brain diseases or systemic diseases. Currently, drug treatment is the main approach.

The so-called drug treatment mainly eliminates or alleviates the symptoms of epilepsy in two ways. One is to affect the central nervous system to prevent or reduce their pathological excessive discharge; the other is to increase the excitation threshold of normal brain tissue, weaken the spread of focus excitation, and prevent the recurrence of epilepsy.

Clobazam is a long-acting benzodiazepine that regulates GABAergic nerve transmission by increasing the opening frequency of chloride channels.

GABAA has a positive steric regulatory effect, resulting in an increase in the permeability of chloride ions in the nerve cell membrane, resulting in hyperpolarization and stabilization of the membrane. In addition, clobazam also has the effect of upregulating GABA channels 1 and 3.

Since the 1980s, clobazam has been used as an anti-epileptic drug in more than 100 countries; early clinical research results show that more than half of patients have a reduction in seizure frequency by more than 50%; the most common adverse reactions of clobazam are drowsiness or sedation. In the opinion of professional doctors, clobazam has the characteristics of "accurate efficacy, high safety, and good tolerance".

As a good drug for curing epilepsy, why is clobazam related to "controlled drugs"?

The special mechanism of action of clobazam can effectively treat epilepsy. However, the mechanism of action of clobazam is also a double-edged sword. Like many psychotropic drugs, clobazam belongs to the benzodiazepine family of drugs. This means that the defects and hidden dangers of benzodiazepines may also exist with clobazam, and patients who use them will be at risk of abuse and addiction.

The Office of the National Narcotics Control Commission pointed out in a 2017 "Notice on the Issuance of the Dependence Conversion Table for 100 Controlled Varieties of Narcotic Drugs and Psychotropic Substances" that 1 gram of clobazam is equivalent to 0.1 mg of heroin. Therefore, the ban on clobazam is not unjust.

Clobazam is both an angel and a devil. In order to meet the urgent needs of epilepsy patients, the former National Health and Family Planning Commission and other institutions organized experts to propose the "Second Batch of Suggested List of Children's Drugs for Encouraging Research and Development Application" based on the current situation of children's drugs that have not been registered and marketed in mainland China and are urgently needed for clinical use. Clobazam 10mg tablets are included in this list at number ten. In other words, on the premise of ensuring safety, clobazam is expected to be used or approved for use in China.

However, distant water cannot quench local thirst, and the approval of clobazam will take time. Between the huge demand and the market gap, the illegal behavior of purchasing on behalf of others has arisen. Patients are eager for treatment and are easily blinded by unscrupulous purchasing agents. They may even hit the bottom line of the law like Ms. Li. Therefore, Medical Companion Travel calls on patients to keep their eyes open and choose legal platforms like Medical Companion Travel to purchase overseas drugs.