氨己烯酸用法用量

Vigabatrin is indicated for the treatment of epilepsy in which other anti-epileptic drugs are ineffective, especially partial seizures. Vigabatrin can also treat infantile spasms (West syndrome, West syndrome). It works by irreversibly inhibiting GABA aminotransferase (GABA-T) and increasing GABA concentration in the brain. Vigabatrin is the drug of choice for TSC epilepsy in foreign countries. In terms of controlling TSC epileptic seizures, about 95% of children have a good response to vigabatrin tablets. Once a seizure is discovered, regardless of the form, vigabatrin is the first choice, and the effect is better when used for the first time. Especially for infantile spasms (peak arrhythmia on the electroencephalogram), vigabatrin should be taken as soon as possible.

Vigadrone usage and dosage: Vigadrone needs to be started under the guidance of a doctor with experience in treatment. The recommended dosage is as follows: the maximum dosage of Vigadrone for adults is 2-3g per day, and 1g per day is appropriate at the beginning. Then based on the response to the medication, if the response is good, it can be increased by 0.5g per week, and finally reaches a dose of 2-3g per day.

The recommended dosage for Vigadrone treatment in children is 40 mg/kg/day. Continuous medication should be judged according to the patient's weight. The recommended dosage for children weighing 10-15kg is 0.5-1g/day; the recommended dosage for 15-30kg is 1-1.5g/day; the recommended dosage for 30-50kg is 1.5-3g/day; >50kg 2-3g/day. If the patient has special circumstances, he or she needs to inform the doctor before starting treatment with Vigadrone, and the doctor will make adjustments to the patient's medication based on the actual situation to avoid harm to the patient due to incorrect medication.

Side effects of the drug are basically inevitable during treatment. Common side effects of Vigabatrin include fatigue/drowsiness/headache/dizziness/confusion/depression. Occasionally aggressive behavior and psychosis/memory loss/double vision/weight gain/gastrointestinal disorders/edema/hair loss. Nystagmus/nervousness/irritability/ataxia/paresthesia/tremor, etc. may also occur.

Vigadrone can cause permanent vision loss in infants, children, and adults, including progressive and permanent bilateral concentric visual field constriction in >30% of patients, ranging in severity from mild to severe, including tunnel vision to visual acuity fixed within 10 degrees, and can result in disability.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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