呲仑帕奈的禁忌和注意事项

Parampanel is indicated for the add-on treatment of partial-onset epilepsy (with or without secondary generalized seizures) in adults and children 12 years of age and older. Take once a day, before going to bed, on an empty stomach or with food. Perampanel should be swallowed whole and should not be chewed, crushed, or broken. Since there are no marks on the medicine, this product cannot be opened evenly. Today let’s learn about the taboos and precautions of Parapanel.

1. Suicidal ideation.

2. Various neurological diseases.

3. Oral contraceptives.

4. Fall.

5. Attack.

6. Other symptoms of mental illness.

7. Social environment.

8. Potential for abuse.

Suicidal ideation and behavior have been reported collectively in patients receiving epilepsy drugs for a variety of indications, and a meta-analysis of randomized, placebo-controlled trials of antiepileptic drugs also showed a small increased risk of suicidal ideation and behavior. The mechanism by which these risks arise is unknown, but current data cannot rule out the possibility that these risks are increased when using perampanel. Therefore, patients should be tested for signs of suicidal ideation and behavior, and appropriate treatment should be considered. Patients (and their caregivers) should be informed that they should seek medical attention if they develop suicidal ideation or signs of suicidal behavior.

Perampanel, the active substance in Fycompa, is an anti-epileptic drug. Epilepsy is caused by excessive electrical activity in the brain. While the exact mechanism by which Fycompa works is not fully understood, it is thought to block the effects of the neurotransmitter glutamate. Neurotransmitters are naturally occurring chemicals in the nervous system that allow nerve cells to communicate with each other. Glutamate is the primary stimulatory neurotransmitter in nerve cells that can initiate and sustain epileptic seizures. Therefore, by blocking the effects of glutamate, Fycompa is thought to stop epileptic seizures.

It is contraindicated in those allergic to the active ingredient of parampanel or lactose. Because of its lactose content, valampanel should not be used in patients with rare hereditary galactose intolerance, Lapp lactase deficiency, or glucose-galactose dystrophy.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.