服用法国赛诺菲的喜保宁需要注意什么？

It is a new type of anti-epileptic drug that was approved by the US FDA in 2009. It is mainly used for the treatment of infantile spasms between one month and two years old. It is especially more effective in children with epilepsy caused by tuberous sclerosis than other anti-epileptic drugs. In addition, Vigabatrin, as an add-on therapeutic drug, can be used to treat refractory complex partial seizures in adults. French sanofi-aventis is the largest pharmaceutical company in Europe and the third largest in the world. It was established in 2004 through the merger of Sanofi-Synthelabo and Aventis. So, what should you pay attention to when taking France's Sanofi Vigabatrin?

Anemia: Associated with decreased hemoglobin and hematocrit; cases of significant decreases in hemoglobin (<8 g/dL) or hematocrit (<24%) have been reported. Central Nervous System Depression: May cause central nervous system depression, which may impair physical or mental abilities; patients must be cautioned not to perform tasks that require mental alertness (such as operating machinery or driving). Edema: Peripheral edema and oedema have been reported to be associated with hypertension, heart failure, weight gain, and renal or hepatic insufficiency. Neurotoxicity: Intramyelin edema has been reported (rarely) in infants. Patients must be closely monitored for potential neurotoxicity (observed in animal models but not in adults). Peripheral Neuropathy: Peripheral neuropathy occurs in adult patients and manifests as numbness or tingling in the toes or feet, diminished vibration or position sensation in the distal lower extremities, or progressive loss of reflexes. Suicidal Ideation: Patients taking antiepileptic medications are at increased risk for suicidal ideation/behavior. Monitor changes in the patient's behavior and notify the doctor immediately if suicidal thoughts or symptoms of depression occur. Vision loss: Vibatrin can cause permanent vision loss in infants, children, and adults. Weight gain: The average weight gain of adults is 3.5 kg, and the average weight gain of pediatric patients is more than 7%. Psychotic Behavior: Psychotic/anxiety reactions may occur more frequently in patients with a history of psychosis/psychosis. Renal Impairment: Use with caution in patients with renal impairment; adjust dosage in children and adults with renal impairment (CrCl <80 ml/min). Seizures: May cause increased seizure frequency in some patients; use with caution in patients with myoclonic epilepsy.

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