氨己烯酸片(喜保宁)可以长期服用吗

(Vigabatrin) is an anti-epileptic drug with an obvious mechanism of action. Treatment with Vigabatrin causes an increase in the concentration of GABA (gamma-aminobutyric acid), which is the main substance that inhibits neurotransmitters in the brain. This is because Vigabatrin is an irreversible inhibitor of GABA transaminase, the substance that breaks down GABA. The decrease in GABA transaminase will inevitably lead to an increase in GABA concentration.

The use of vigabatrin tablets (Vigabatrin) should be carried out under the guidance of an epilepsy expert or a child neurologist. Reactions after taking the medication should be reported to the doctor promptly. Vigabatrin is an oral medication that can be taken once or twice a day, before or after meals. It is advisable to drink half a glass of water when taking the medication.

If your epilepsy condition does not improve after taking it for enough time, you should stop taking Vigabatrin. At this time, vigabatrin tablets (Vigabatrin) should be gradually stopped under the supervision of a doctor.

Children younger than 6 years old are prone to choking when taking tablets, so please pay attention to this.

Adult dosage: The maximum dosage is 2-3 grams per day. It is appropriate to start taking it at 1g a day, and then according to the reaction after taking the medicine, if the reaction is good, it can be increased by 0.5g every week. Finally, the daily dosage is reached 2-3g. The maximum daily dosage should not exceed 3g.

There is no necessary connection between dosage and efficacy. The duration of action of the drug depends on the resynthesis rate of GABAergic transaminase rather than the drug concentration in the blood.

Dosage for the elderly and patients with renal impairment: Because Vigabatrin is digested by the kidneys, caution should be exercised when the elderly and patients with a creatinine elimination rate less than 60 ml/min (60 ml per minute) take this drug. For both groups, reductions in dosage and frequency should be considered. A small amount of medication may be effective for both types of people. Such patients should be monitored for signs of unusual sedation or confusion.

Warnings and precautions for use: Vigabatrin should not be used as the only treatment for epilepsy. Long-term use may cause side effects.

After patients took vigabatrin tablets (Vigabatrin), the incidence of visual field defects was very high (about one-third). This often occurs after using Vigabatrin for several months to several years. Visual field defects can be severe, which can have real consequences for the patient. Most patients with visual field loss have no obvious symptoms. Therefore, this adverse effect can only be confirmed through systemic examination, which is often only possible in patients over 9 years of age. In this regard, a method based on field-specific visual evoked potentials was specially developed to detect visual impairment in children aged 3 years and above. This method can be obtained from the Vigabatrin Tablets (Vigabatrin) company. However, so far, this method has not been legally validated for detecting visual field defects caused by taking vigabatrin tablets (Vigabatrin).

Patients must pay attention when taking (Vigabatrin), and seek medical treatment in time if toxic or side effects occur.

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