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Vigabatrin tablets have anti-epileptic effects. Its mechanism of action is to irreversibly inhibit GABA aminotransferase (GABA-T) and increase the concentration of GABA in the brain to exert its effects. Clinical research results show that vigabatrin is an effective and safe anti-epileptic drug in the treatment of children with severe epilepsy, and is also effective in epilepsy patients with intellectual disabilities. Vigabatrin tablets are absorbed rapidly after oral administration, and food does not affect its absorption rate. Peak plasma concentration is reached 2 hours after taking the drug, t1/2 is 5-7 hours, and a single dose of 1-3g is taken. The pharmacokinetics show a dose-linear relationship, the apparent volume of distribution is about 0.8L/kg, and the relative bioavailability is 92±11%. Vigabatrin tablets are suitable for the treatment of intractable partial epilepsy, especially for intractable childhood epilepsy.

The generic name of vigabatrin and the brand name of Sabril are vigabatrin, a drug used to treat epilepsy and infantile spasms. It was developed in the 1980s. The treatment was approved in the UK in 1989. On August 21, 2009, the U.S. FDA approved Sabril as a monotherapy for pediatric patients 1 month to 2 years old, where the potential benefits of infantile spasms outweigh the potential risk of vision loss, and as an adjunctive (additional) treatment for adult patients with refractory complex partial epilepsy (CPS). The generic version of Sabril (vigabatrin, 500mg tablets) was launched in the United States. The drug was approved by the FDA in mid-January 2019 and was the first generic version of Sabril (vigabatrin tablets) to enter the U.S. market.