Agamree怎么使用

Agamree is developed by Swiss Santhera Pharmaceuticals. The active ingredient is Vamorolone, also known as Vamorolone, Vamorolone, etc. It is suitable for the treatment of Duchenne muscular dystrophy 2 years old and above.

How to use Agamree

The following is the specific medication guidance for Agamree, but there are individual differences between patients. Please consult a professional doctor for specific medication plans.

Routine dosage and medication method

The recommended dosage is 6 mg/kg body weight orally once a day, taken with meals to increase absorption rate. For patients weighing more than 50 kg, the maximum daily dose should not exceed 300 mg. Shake the solution well for 30 seconds before use, use the included 5mL oral syringe to accurately measure the dose, and put it directly into your mouth. Unused medicinal solution within 3 months after opening the bottle must be discarded and cannot be used further.

Dose adjustment for special groups

Patients with mild to moderate hepatic impairment need to reduce the dose to 2 mg/kg/day, and the upper limit is 100 mg for those weighing over 50 kg. When combined with strong CYP3A4 inhibitors, the dose is adjusted to 4 mg/kg/day, with an upper limit of 200 mg. If the drug needs to be discontinued after long-term use, the dose must be gradually reduced to avoid causing adrenal insufficiency.

All routine vaccinations need to be completed before the first dose, and live vaccines need to be vaccinated 4-6 weeks in advance. If you switch from other glucocorticoids to Agamree, you can replace it directly without excessive dose reduction, but your adrenal function needs to be monitored. When a dose is missed, if it is close to the time of the next dose, the missed dose should be skipped to avoid doubling the dose.

Agamree’s side effects

The use of Agamree may be accompanied by a variety of adverse reactions. Timely identification and treatment can reduce health risks.

Cushingoid changes and endocrine problems

Long-term use of Agamree may lead to facial roundness, weight gain, or skin thinning. If symptoms are obvious, you need to contact your doctor to adjust the dosage and regularly monitor blood sugar, bone density and adrenal function. It is recommended to supplement calcium and vitamin D to reduce the risk of osteoporosis.

Mental and behavioral abnormalities

Some patients experience mood swings, insomnia or depression. Families should closely observe mood changes. If symptoms continue to worsen, they need to suspend medication and seek psychological intervention. Doctors may prescribe sedative drugs for short-term auxiliary treatment.

If blurred vision or increased intraocular pressure occurs during medication, you need to undergo an eye examination to rule out the possibility of glaucoma or cataracts.

Who should use Agamree with caution

Some patients need to use Agamree with special caution due to physiological conditions or diseases. The following are specific groups and precautions.

Pregnant and lactating women

Pregnant women need to evaluate potential risks when using it. High doses may affect fetal development, such as low birth weight or maxillofacial clefts in newborns. Breastfeeding women need to weigh the pros and cons of breastfeeding. If medication is necessary, it is recommended to suspend breastfeeding. Both groups of people need to strictly follow doctor's instructions before use.

Patients with impaired liver function

Patients with mild to moderate hepatic impairment need to reduce the dose to 2 mg/kg/day and monitor liver function indicators regularly. There is a lack of clinical data for patients with severe hepatic insufficiency, and Agamree is not recommended. If jaundice or abdominal pain occurs during medication, the medication should be stopped immediately and seek medical attention.

The safety of children under 2 years old has not been verified and the use of Agamree is prohibited. Due to the lack of clinical data in elderly patients, the benefits and risks need to be carefully evaluated, and the starting dose of Agamree can be appropriately reduced.