那他霉素滴眼液作用与功能是什么,效果好吗

Fungal corneal ulcer is an infectious corneal disease with a high rate of blindness. It often occurs after vegetative corneal trauma and is caused by direct invasion of fungi into the cornea. The main pathogenic bacteria are Aspergillus, Fusarium, Candida albicans, Cephalosporium, etc. The treatment of fungal corneal ulcers currently lacks broad-spectrum, high-efficiency, antifungal ideal drugs, and the treatment is very difficult. Since its approval in the 1960s, 5% is still the only finished antifungal eye drop certified and approved for use by the U.S. Food and Drug Administration. Other antifungal drugs require temporary preparation as eye drops. So, what is the role and function of Natamycin Eye Drops, and is it effective?

What are the effects and functions of natamycin eye drops?

Natamycin is a tetraene antibiotic extracted from Streptomyces natalensis. It has in vitro activity against a variety of yeasts and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Its mechanism of action is through the combination of drug molecules with the sterol part of the fungal cell membrane to form a polysterol complex, which changes the permeability of the cell membrane and depletes the basic cellular components in the fungal cells. This antifungal effect is related to the drug dose. Natamycin has no effect on Gram-positive and Gram-negative bacteria in vitro. Clinically, 5% natamycin suspension is used for eye drops. It has stable properties, can be tolerated by the eyes, is broad-spectrum, highly efficient, and non-toxic.

Are natamycin eye drops effective?

Topical application of 5% natamycin eye drops, because of its high density, can accumulate in the corneal parenchyma layer to reach an effective concentration, giving full play to its pharmacological effect. Symptoms can be significantly improved one day after eye drops, and the ulcer surface is also obviously localized. Therefore, it is used for the early treatment of fungal infections. The effect is very significant, so it can be regarded as the first choice for the treatment of shallow and middle corneal ulcers.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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