那他霉素滴眼液为何如此缺货?到底是何方“神圣”?

Recently, the Internet has been flooded with various posts, Q&A and other information about the "out of stock" of Natamycin Eye Drops. What is so "sacred" about Natamycin Eye Drops that so many people are "looking for"? The author will take 3 minutes to review this antifungal drug Natamycin Eye Drops.

So what kind of medicine is Tamamycin Eye Drops? So popular?

Natamycin eye drops are a broad-spectrum antifungal and anti-inflammatory drug that has a very strong inhibitory effect on Candida, Blastomyces, Aspergillus and other species of bacteria. Currently, it is mainly used clinically to treat ocular fungal infections, such as fungal blepharitis, keratitis, etc.

Natamycin eye drops are one of the most effective antifungal drugs currently available, but they are a bit expensive, with imported drugs costing thousands of dollars each.

The mechanism of action of natamycin eye drops

Natamycin, as a tetraene polyene antibiotic extracted from Streptomyces NATALENSIS, has the ability to kill a variety of filamentous fungi and yeasts in vitro, including Penicillium, Fusarium, Cephalosporium, Aspergillus, and Candida. The mechanism of action of Natamycin Eye Drops is that the fungal cell membrane and drug molecules combine to form a polysterol complex, which improves the permeability of the cell membrane and promotes the depletion of components within the fungal cells. Although the effects of many antifungal drugs are dose-dependent, natamycin is still an antifungal drug with obvious effects.

Natamycin has no effect on Gram-negative and Gram-positive bacteria in vitro. Topically applied natamycin can achieve effective concentrations within the corneal stromal layer but not in the intraocular fluid. 5% natamycin administered locally cannot be absorbed systemically. As with other polyolefin antibiotics, very minimal amounts of this drug are absorbed through the gastrointestinal tract.

Natamycin eye drops dosage and dosage

Patients need to shake natamycin eye drops thoroughly before using them. When treating fungal keratitis, patients need to use 5% natamycin. The optimal starting dose is one drop at a time, once every 1 to 2 hours, and can be dropped into the conjunctival sac. After 3 to 4 days, it is still one drop at a time, but only 6 to 8 times a day. The treatment cycle needs to last 14 to 21 days, and patients with severe infections can continue to use it until the fungal keratitis subsides.

Most patients can generally gradually reduce the dosage of the drug every 4 to 7 days. For patients with fungal blepharitis or conjunctivitis, the starting dose can be smaller, one drop at a time, 4 to 6 times a day.

Precautions when using natamycin eye drops

Natamycin eye drops are an antifungal and anti-inflammatory drug, mainly used to treat fungal keratitis, conjunctivitis, etc. Patients need to actively follow the doctor's recommended medication during treatment to prevent the progression of the disease. If you get sick, you must pay attention to eye hygiene. You must not rub your eyes with your hands. At the same time, you must give your eyes sufficient rest to avoid overexertion. So, what should patients pay attention to when using natamycin eye drops?

Natamycin eye drops are for eye use only and cannot be injected. If natamycin eye drops have no effect after 7 to 10 days, you need to pay attention to whether the fungus causing the infection is not sensitive to natamycin. It is necessary to conduct clinical evaluation and laboratory test results to determine whether treatment with natamycin eye drops can be continued. Patients need to regularly apply natamycin eye drops to the epithelial ulcer or fornix during use. Since the number of patients using natamycin eye drops in China is limited, some unobserved adverse reactions may occur.

Therefore, patients using natamycin eye drops need to be checked twice a week. If serious side effects occur, the medication needs to be stopped immediately. Another thing to note is that patients should not touch the mouth of the bottle to prevent the liquid from being contaminated and causing other symptoms.

Recently, natamycin eye drops have been seriously out of stock, and the specific reason is unknown, but it is still available in some regular medical institutions (such as Medical Companion Travel). Warm reminder: Although the goods are urgently needed, you still need to be careful when picking up medicines.