立他司特(Xiidra)的功效与作用以及疗效？

Xidralast (Xiidra) is a lymphocyte function-associated antigen-1 antagonist, mainly used to treat dry eye syndrome. Clinical studies have shown that Ritalast can significantly improve eye moisture and reduce the severity of dry eye symptoms, and can quickly relieve uncomfortable symptoms caused by dry eyes.

Efficacy and role of Xiidra (Xiidra)

Eye drops relieve dry eye symptoms by regulating eye inflammation and immune response. Ritalast is a new type of small molecule integrin antagonist that can bind to LFA-1 on the surface of leukocytes, effectively blocking the reaction between LFA-1 and intercellular adhesion molecule-1, inhibiting the inflammatory response on the ocular surface, thereby treating dry eye symptoms and relieving symptoms such as dry eyes, foreign body sensation, fatigue, photophobia, and tearing.

Ritalast's

The efficacy and safety of Ritalast 0.5% eye drops were evaluated in four randomized controlled trials over 12 weeks, and one trial evaluated the safety over 1 year. Ritalast produced statistically significant improvements in inferior corneal fluorescein staining scores and ocular dryness scores in most trials and may serve as an option for patients with inadequate response to artificial tears.

The efficacy of Ritalast eye drops 5% was compared with vehicle in patients with dry eye syndrome in one 12-week Phase 2 study and three 12-week Phase 3 studies. Collectively, the results of these trials support the therapeutic efficacy of ritasilast eye drops 5% in improving dry eye symptoms, namely change in visual analogue score of ocular dryness from baseline to day 84 and change in inferior corneal fluorescein staining score from baseline to day 84.

In four 12-week randomized, multi-center, double-blind, vehicle-controlled studies, the safety and efficacy of ritasilast in the treatment of dry eye were evaluated in 1,181 patients. Patients were randomized to receive either Ritalast or placebo, administered twice daily.

Significant reductions in EDS and ICSS were observed in all studies on days 42 and 84 in favor of ritalast.

Usage and Dosage

Instill 1 drop of Ritalast into each eye, twice a day, with an interval of approximately 12 hours.

Contraindications

Contraindicated in persons with known allergy to Ritalast or any other ingredient.

The current reference price of Shire's Libalast in foreign markets is around $3,982 per box. You need to purchase it at your own expense, and it is temporarily unavailable in China. You need to go abroad or choose a domestic overseas medical service institution to purchase it.

Specific operation steps

1. Take out an aluminum foil bag from the Litalast box, open the bag, take out the disposable container strip, and remove a disposable container from the reagent strip.

2. Hold the Litalast container vertically and tap the top of the container until all the solution is at the bottom of the container.

3. Unscrew the label and open the disposable container of Litalast, making sure that the tip of the disposable container does not come into contact with anything to avoid contamination.

4. Tilt your head back.

5. Place the tip of the disposable container of Ribalast close to your eyes, but do not touch them.

6. Gently squeeze the disposable container so that a drop of Ritasilast falls between the lower eyelid and the eye.

7. Repeat the above steps for the other eye.

Reference:

Keating GM. Lifitegrast Ophthalmic Solution 5%: A Review in Dry Eye Disease. Drugs. 2017 Feb;77(2):201-208. doi: 10.1007/s40265-016-0681-1. PMID: 28058622.

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