Qlosi滴眼液主治什么病

Qlosi eye drops are a cholinergic agonist that was approved for marketing by the US FDA in October 2023.

Indications of Qlosi eye drops

It is suitable for the treatment of presbyopia in adults.

Qlosi eye drops usage and dosage

1. Specific usage

Put one drop of Qlosi eye drops into each eye. To achieve effects lasting up to 8 hours, repeat eye drops for a second time 2-3 hours later.

2. Frequency of medication

It can be used daily or as needed, up to twice a day.

3. Interval administration

If multiple topical ophthalmic drugs are used at the same time, there must be an interval of at least 5 minutes between administration of different drugs.

4. Drug overdose

Systemic toxic reactions after topical use of pilocarpine in the eyes are rare, but sensitive patients may occasionally experience sweating and gastrointestinal hyperfunction.

Accidental ingestion can cause sweating, salivation, nausea, tremors, slowed pulse and decreased blood pressure.

For moderate overdose, spontaneous recovery is expected and may be assisted by intravenous fluids to correct dehydration. Atropine, the pharmacological antagonist of pilocarpine, should be used in patients exhibiting severe intoxication.

The pictures come from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Qlosi Eye Drops Medication for Special Populations

1. Pregnancy

There are currently no adequate and well-controlled studies on the use of Qlosi Eye Drops in pregnant women to inform drug-related risks. Oral pilocarpine was administered to pregnant rats during the organogenesis and lactation periods, and no adverse effects occurred at clinically relevant doses.

2. Lactation period

There is no data on the presence of pilocarpine in human milk, its impact on breast-fed infants, or its effect on milk secretion. It is impossible to tell the risk of Qlosi eye drops to lactating infants. Following a single oral administration, pilocarpine and/or its metabolites are excreted in the milk of lactating rats.

Systemic exposure to pilocarpine after topical ocular administration is low, and it is unknown whether measurable levels of pilocarpine will be present in breast milk following ocular use of Qlosi eye drops.

The developmental and health benefits of breastfeeding should be considered, along with the mother's clinical need for Qlosi Eye Drops and any potential adverse effects of Qlosi Eye Drops on the breastfed child.

3. Pediatric use

Presbyopia is an age-related disease that does not occur in the pediatric population.

4. Elderly use

Clinical studies of Qlosi eye drops did not include subjects aged 65 and over to determine whether their responses were different from those of younger subjects. The safety and effectiveness in patients over 65 years old have not yet been established.

Precautions for Qlosi eye drops

1. Blurred vision

Qlosi eye drops may cause accommodation spasm. If the patient's vision is unclear (such as blurred vision), do not drive or operate machinery.

In addition, patients may experience temporary dimming or darkening of vision when using Qlosi eye drops. Patients are advised to be cautious when driving at night and engaging in other hazardous activities in poorly lit environments.

2. Risk of retinal detachment

Rare cases of retinal detachment have been reported when using miotic agents in susceptible individuals and patients with existing retinal diseases. A retinal examination is recommended for all patients before starting treatment.

3. Iritis

When iritis is present, it is not recommended to use Qlosi eye drops because synechiae between the iris and the lens (posterior iris synechiae) may form.

4. Wearing contact lenses

Contact lens wearers should be advised to remove their lenses before applying Qlosi eye drops and to wait 10 minutes after administration before putting them back on.

5. Risk of eye damage or contamination

To prevent eye damage or contamination, avoid allowing the tip of the single-dose vial to come into contact with the eyes or any other surface.