美国安进地舒单抗注射液的安全性高吗

Xgeva is a monoclonal antibody drug developed by the American company Amgen that targets the RANKL protein. Amgen Biopharmaceutical Company (Amgen) is the world's leading innovative biopharmaceutical R&D and production company, and has achieved major breakthroughs in the fields of human genome, tumor biology, neuroscience, hematology and other fields. At this stage, denosumab Xgeva is mainly used in postmenopausal patients with osteoporosis or patients who are intolerant to other drug treatments. There are also studies reporting that denosumab Xgeva is used to treat the resorption and destruction of bone structure caused by bone metastasis after breast cancer and prostate cancer.

Is American Amgen’s denosumab injection safe?

FREEDOM, a 3-year randomized, double-blind, placebo-controlled Phase III clinical trial, evaluated the efficacy and safety of denosumab Xgeva in the treatment of osteoporosis in postmenopausal women. Patients were randomly assigned to receive denosumab Xgeva or placebo. The primary outcome measure was the incidence of new vertebral fractures over the 3-year period, and secondary outcomes included the incidence of hip and nonvertebral fractures and the time to first fracture during the observation period. Approximately 23% of the subjects had a history of at least 1 fracture before entering the trial. All patients also received daily supplements of 1,000 mg of vegetarian calcium and 400 to 800 IU of vitamin D.

The results showed that compared with the placebo group, the denosumab Xgeva treatment group reduced the incidence of new vertebral fractures by 68%, the incidence of hip fractures by 40%, and the incidence of non-vertebral fractures by 20%.

The therapeutic effect of denosumab Xgeva injection is remarkable, but the use of this drug for treatment will also produce certain side effects or adverse reactions. The side effects of denosumab include: back pain/limb pain/musculoskeletal pain/hypercholesterolemia/ Cystitis/anemia/angina/atrial fibrillation/vertigo/abdominal pain/bloating/gastroesophageal reflux disease/peripheral edema/weakness/upper respiratory tract infection/pharyngitis/shingles/spinal osteoarthritis/sciatica/insomnia/rash/itching, etc.

The above is the introduction to Xgeva. If patients have other questions about denosumab Xgeva (such as drug prices, purchase channels, etc.), they can consult the medical companion travel service.

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