地舒单抗在国内售价多少？

It is a new type of RANKL inhibitor developed by Amgen. It is a fully human monoclonal IgG2 antibody of RANKL. It has high affinity and specificity for the soluble, transmembrane form of human RANKL. In patients with giant cell tumors of bone, inhibition of RANKL secreted by tumor stromal components with denosumab significantly reduced or eliminated osteoclast-like tumor-associated giant cells. As a result, osteolysis is reduced, giant cell tumor progression is slowed, and the proliferative matrix is ​​replaced by dense nonproliferative, differentiated woven new bone, thereby improving clinical outcomes.

Following the approval of denosumab by the US Food and Drug Administration (FDA) in November 2010, in July 2011, the European Medicines Agency (EMA) also officially approved denosumab for the prevention of SRE in patients with bone metastases from solid tumors. Desosumab is a fully humanized immunoglobulin (Ig) G2 monoclonal antibody prepared using recombinant DNA technology. Its target is receptor activator of nuclear factor-κB ligand (RANKL). The State Food and Drug Administration conditionally approved the listing of denosumab on May 21, 2019. As a new drug, the domestic price of denosumab can be said to be quite high. The domestic price of denosumab with a specification of 120mg/1.7ml bottle/box is 5298$, which makes it prohibitive for many patients.

Fortunately, according to Medical Companion Travel, we learned that the price of 120mg produced by Amgen in the United States is about $3,000. If you need to buy denosumab, you can choose to go abroad to buy the original drug or buy it at home. You can also choose domestic reliable overseas medical institutions (such as Medical Companion Travel) to purchase it. It is 100% authentic and can be shipped directly to your home.

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