地舒单抗注射后多久见效？

, generic name: denosumab/denosumab/denosumab, brand name: Xgeva/Prolia/Angavir is a monoclonal antibody that binds to a protein called RANK ligand (a man-made version of an immune system protein). RANK ligands normally trigger osteoclasts to destroy bone cells, but when denosumab binds to them, this effect is blocked. Desosumab successfully reduced bone pain and reduced tumor growth.

Denosumab is a RANKL inhibitor that inhibits osteoclast activation and development, reduces bone resorption, and increases bone density. Denosumab can be used for the prevention of bone-related events in bone metastases from solid tumors, patients with giant cell tumors of bone who are unresectable or whose surgical resection may cause serious complications, and hypercalcemia in bisphosphonate-resistant malignancies. However, it is not used for the prevention of bone-related events in patients with multiple myeloma.

The usual dose of denosumab is 120 mg subcutaneously (in the upper arm, upper thigh, or abdomen) every 4 weeks. Calcium and vitamin D supplementation should be used when treating or preventing hypocalcemia.

The most common adverse reactions (incidence greater than or equal to 25% of patients) were fatigue/asthenia, hypophosphatemia, and nausea. Denosumab can significantly reduce calcium levels in the blood, and related deaths have been reported. Therefore, treat hypocalcemia before using denosumab and take calcium and vitamin D as directed by your doctor. Tell your doctor right away if you feel cramps, twitching, cramping, muscle stiffness, numbness, or tingling in your fingers, toes, or around your mouth.

How long does it take for the injection to take effect? How long it takes for denosumab to take effect after injection also depends on the patient's own condition and condition. However, the editor here recommends that patients must take the medication correctly in accordance with the doctor's instructions and do not change the time and dosage of the drug on their own, so as to ensure that the drug can play its role faster.