狄诺塞麦对骨巨细胞瘤有效吗？

Zoledronic acid is a commonly used drug in the clinical treatment and prevention of bone metastases, and can effectively prevent or delay the occurrence of bone-related events. Zoledronic acid is generally used for at least 6 months. What to do when resistance to zoledronic acid develops? Don’t worry, (denosumab) is the best choice after drug resistance.

The efficacy of Denosumab Fortifies Bone Density in preventing osteoporosis in postmenopausal women was evaluated in a randomized, placebo-controlled phase III clinical trial, DEFEND (Denosumab Fortifies Bone Density). The average age of the subjects was 59.4 years old, and the spine T-scores were between -1.0 and -2.5 (mean -1.61). They were randomly divided into a treatment group (60 mg of this product for subcutaneous injection, once every 6 months, n = 166) or a placebo group (n = 166). All patients were supplemented with 1,000 mg of calcium every day, and the serum was passed through the subjects' plasma. Levels of 25-hydroxyvitamin D determine the need for vitamin D supplementation. The main evaluation index is the change in spinal BMD measured by dual energy X-ray absorptiometry (DXA) compared with the baseline level.

The results showed that after 24 months, denosumab (denosumab) significantly increased the BMD value of the spine compared with placebo (an increase of 6.5% in the treatment group and a decrease of 0.6% in the placebo group). In addition, the BMD values ​​of all tested sites, including the hip and distal radius, increased significantly in the treatment group. At the same time, markers of bone resorption and formation were significantly reduced. The overall incidence of adverse reactions in the treatment group was similar to that in the placebo group during the observation period. To sum up, the therapeutic effect of denosumab (denosumab) is still good, and patients can buy it with confidence.

In view of the expensiveness of the original drug, most patients chose the drug (denosumab) marketed in Turkey by the American company Amgen. The specification is 120 mg and the price is equivalent to RMB 1,500, which can be said to be high quality and low price. If you have any need to purchase medicines, please consult Medical Travel. We will provide you with convenient and safe channels for purchasing medicines.

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