地诺单抗是哪个国家的？

(Denosumab) is from which country? Denosumab (Denosumab) is a drug produced in the United States that is effective in treating bone metastasis. The price of 120 mg of Denosumab (Denosumab) produced by the American company Amgen is about $3,000. Xgev Denosumab (Denosumab) is a new foreign drug that is not currently on the market in China. If you want to buy Denosumab, you can buy it through the regular overseas medical service company Yibenlv.

Denosumab binds to RANKL, a transmembrane or soluble protein that plays an important role in the formation, function, and survival of osteoclasts, the cells responsible for bone resorption, and regulates the release of calcium from bone. Through RANKL stimulation, osteoclast activity is enhanced, mediating the occurrence of bone metastasis bone pathology in solid tumors. In addition, giant cell tumors of bone contain stromal cells that express RANKL, and osteoclast-like giant cells express RANKL receptors, which signal to each other leading to osteolysis and tumor growth. Denosumab prevents RANKL from activating its receptor RANK expressed on the surface of osteoclasts, precursor cells, and osteoclast-like giant cells.

The therapeutic effect of denosumab (desosumab) in the treatment of bone metastases:

1. In phase II clinical trials, 86% (30/35) of patients with unresectable or recurrent GCTB treated with denosumab (desosomeumab) experienced tumor response (defined as at least 90% disappearance of giant cells or no impact on tumor progression of target lesions for 25 weeks).

2. In the phase II clinical trial, 282 patients were divided into 3 groups. Group 1 was patients with unresectable GCTB, group 2 was patients with postoperative GCTB with severe surgical complications, and group 3 was patients who were previously studied with denosumab. In group 1, 96% of patients showed no progression after 13 months of follow-up, in group 2, 74% of patients did not undergo surgery after 9.2 months of follow-up, and 62% of patients underwent surgery with fewer complications. The pain was significantly reduced after 2 months of use.

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