地舒单抗对骨转移有效果吗？

Is it effective against bone metastasis? Many newly diagnosed patients are relatively unfamiliar with denosumab. Below we have compiled some trials on the effects of denosumab. Let’s learn about its effects together!

Three randomized-double-blind clinical studies confirmed the safety and efficacy of denosumab, with a total of 5,723 patients participating in the studies. These studies compared denosumab (denosumab) with zoledronic acid in patients with breast cancer, prostate cancer, and various other cancers. The studies were designed to measure the time between patients ultimately suffering a fracture or spinal cord compression due to cancer, or requiring radiation or surgery to control pain.

In patients with prostate cancer, denosumab delayed SREs better than zoledronic acid. The median delay in SREs in patients with prostate cancer was 21 months and 17 months with zoledronic acid. In patients with breast cancer, zoledronic acid delayed SREs for a median of 26 months, whereas denosumab did not achieve this level. In patients with other solid tumors, denosumab and zoledronic acid delayed SREs by similar median times. The main solid tumors of the subjects were non-small cell lung cancer, multiple myeloma, renal cancer and small cell lung cancer.

In general, denosumab (denosumab) has a relatively good effect and has different effects in the treatment of different diseases. In other clinical trials, it was able to effectively reduce the incidence of vertebral, non-vertebral and hip fractures in postmenopausal women with osteoporosis.

On May 27, 2019, Amgen China announced that (denosumab) has been approved by the National Medical Products Administration for the treatment of giant cell tumor of bone that is unresectable or that surgical resection may cause severe functional disability, including adults and adolescent patients with skeletal maturity (defined as at least 1 mature long bone and body weight >45 kg). The launch of denosumab in my country has brought new treatment options to domestic patients with bone metastasis and effectively improved the quality of life of patients.