地舒单抗国内哪里有卖？

Where can I buy it in China? In 2019, denosumab, also known as denosumab, was approved for marketing in my country. Its approved indication is to treat giant cell tumors of bone that are unresectable or that may cause severe functional impairment after surgical resection, including adults and adolescent patients with mature bone development (defined as at least 1 mature long bone and a body weight >45 kg). Patients can buy it in some large hospitals in the country with a prescription issued by a doctor.

Giant cell tumor of bone is one of the common primary bone tumors. It is highly aggressive and has a great effect on bone dissolution and destruction. It is a low-grade malignant or potentially malignant tumor.

Desosumab (denosumab) is a RANK ligand (RANKL) inhibitor with a different mechanism of action than currently approved drugs that reduce skeletal complications of tumors. It is a fully humanized monoclonal antibody (IgG2 monoclonal antibody) that specifically targets receptor activator of nuclear factor-κB ligand (RANKL). It prevents RANKL from binding to its receptor substances, inhibits osteoclast activation and development, reduces bone resorption, and increases bone density.

Desosumab is administered by injection, 120 mg subcutaneously in the upper arm, upper thigh, or abdomen, once every 4 weeks, with calcium and vitamin D when needed to treat or prevent hypocalcemia. The most common side effects are: fatigue/weakness, hypophosphatemia, nausea, dyspnea, diarrhea, hypocalcemia, cough, and headache.

The results of three published key clinical trials showed that compared with zoledronic acid, denosumab (denosumab) prolonged the time to the patient's first adverse bone event (ARE) by 17%, or significantly delayed the median time to the first SRE by 8.2 months (27.6 months vs. 19.4 months). Desosumab also extended the time interval from the first time to the recurrence of SRE in the study by 18%, and the effect was very significant.

Since the price of domestic original drugs is relatively high, in addition to buying drugs in domestic hospitals, we can also choose to buy Amgen’s (denosumab) marketed in Turkey, which is relatively cheap. The specification is 125mg/1ml tube/box, and the equivalent price in RMB is around 3,000$.