Denosumab哪里有卖呢？

With changes in diet and lifestyle and the extension of life expectancy, osteoporosis has become one of the most common diseases threatening human health in modern society. It is a bone resorption inhibitor with a unique mechanism of action. It specifically targets receptor activator of nuclear factor kappa B (RANK) ligand, inhibits the activation and development of osteoclasts, reduces bone resorption, and increases bone density. Where can I buy Denosumab?

Denosumab is currently on the market in many countries, and patients can purchase it with a prescription.

A multi-center, randomized, double-blind, placebo-controlled phase III clinical trial involving 7808 patients for 3 years evaluated the safety. The mortality rates from all causes in the treatment group and placebo group were 1.8% and 2.3% respectively; the incidence rates of non-fatal serious adverse events in the treatment group and placebo group were 25.0% and 24.2% respectively; 2.4% and 2.1% of patients in the treatment group and placebo group withdrew from the trial due to adverse events, respectively. The most common adverse reactions reported in clinical trials were back pain in 34.7%, extremity pain in 11.7%, musculoskeletal pain in 7.6%, hypercholesterolemia in 7.2%, and cystitis in 5.9%. The most common adverse reactions that led to drug discontinuation were breast cancer, back pain, and constipation. Other common adverse reactions include: anemia 3.3%, angina pectoris 2.6%, atrial fibrillation 2.0%, dizziness 5.0%, abdominal pain 3.3%, flatulence 2.2%, gastroesophageal reflux disease 2.1%, peripheral edema 4. 9%, weakness 2.3%, upper respiratory tract infection 4.9%, pneumonia 3.9%, pharyngitis 2.3%, herpes zoster 2.0%, spinal osteoarthritis 2.1%, sciatica 4.6%, insomnia 3.2%, rash 2.5%, and pruritus 2.2%.