Xgeva的用法和用量

It is the first approved monoclonal antibody that specifically targets RANK ligand. It specifically targets nuclear factor κB receptor activator ligand (RANK), inhibits the activation and development of osteoclasts, reduces bone resorption, and increases bone density. What is the usage and dosage of Xgeva?

(1) Xgeva can only be administered by subcutaneous injection, not intravenous infusion, intramuscular infusion or intradermal injection. (2) Solid tumor bone metastasis: 120mg once every 4 weeks, injected subcutaneously in the upper arm, thigh or abdomen. (3) Giant cell tumor of bone: 120 mg once every 4 weeks, subcutaneous injection, and another 120 mg on day 8 and day 15 in the first month of treatment. (4) Administer calcium and vitamin D appropriately to prevent hypocalcemia. (5) Malignant hypercalcemia: 120 mg once every 4 weeks, subcutaneous injection, and another 120 mg on day 8 and day 15 in the first month of treatment. The medication is injected under the skin in the upper arm, thigh, or abdomen.

Be cautious or avoid using it in the following situations? Use with caution in patients who are concurrently taking immunosuppressants or have compromised immune function. There are currently no studies on the effectiveness and safety of this product for children, so it is not recommended for children. There is no need to adjust the dosage for the elderly and patients with renal insufficiency. For patients with severe renal insufficiency and those undergoing dialysis treatment, blood calcium monitoring should be carried out, and calcium and vitamin D supplementation should be paid attention to. It is not yet clear whether this product can be excreted in breast milk. Breast-feeding women should weigh the importance of this product and choose to stop taking the drug or stop breastfeeding. Xgeva can interact with some medications. If you are taking other medicines, be sure to inform your doctor before using Xgeva, and ask your doctor whether and how to use the medicine.

Is it prohibited to use Xgeva under the following circumstances? Not suitable for pregnant women. Contraindicated in patients with hypocalcemia. It is prohibited for patients who are allergic to any component of this product.