地舒单抗哪里有售？

Where to buy it? At present, the most cost-effective denosumab is sold in Turkey by the American company Amgen. The specification is 125mg/1ml tube/box, and the price is equivalent to RMB 3,000. It can greatly reduce the financial pressure of patients.

Desosumab is the first approved monoclonal antibody that specifically targets RANK ligand. RANK ligand is a transmembrane or soluble protein that is necessary for osteoclasts to maintain their structure, function, and survival. The mRNA of human RANKL is mainly found in bones, bone marrow and lymphoid tissues. Its main function in bones is to stimulate the differentiation and activity of osteoclasts and inhibit the apoptosis of osteoclasts. Osteoclasts are responsible for bone resorption, and osteoclast precursors must have low levels of macrophage colony-stimulating factor and RANKL during their differentiation into mature osteoclasts.

In 2018, denosumab was included in the list of overseas new drugs in urgent clinical need (first batch) and entered the rapid review channel of the National Medical Products Administration. This approval makes denosumab the first and currently the only drug for the treatment of giant cell tumor of bone, bringing patients an innovative treatment option to control disease progression and improve quality of life.

On May 27, 2019, Amgen China announced today that denosumab has been approved by the National Medical Products Administration for the treatment of giant cell tumors of bone that are unresectable or whose surgical resection may cause severe functional disability, including adults and adolescent patients with skeletal maturity (defined as at least 1 mature long bone and a body weight ≥45 kg).

Although denosumab is already on the market in my country, it is not available in all hospitals because it is conditionally available. Moreover, the price of the original drug when it is launched in my country is usually relatively high, which is often unaffordable for ordinary patient families.

The ones sold in Turkey are more popular among patients because they are cheaper. If it is convenient for patients to go abroad, they can buy them by themselves, but they must choose a regular Turkish pharmacy. If it is not convenient for you to go abroad, you can also ask for medical companion travel clothes to purchase.