地诺单抗中国售价多少？

It is the first approved monoclonal antibody specifically targeting RANK ligand. RANK ligand is a transmembrane or soluble protein that is necessary for osteoclasts to maintain their structure, function, and survival. Human RANKL mRNA is mainly found in bones, bone marrow and lymphoid tissues. Its main function in bones is to stimulate the differentiation and activity of osteoclasts and inhibit the apoptosis of osteoclasts. Osteoclasts are responsible for bone resorption, and osteoclast precursors must have low levels of macrophage colony-stimulating factor and RANKL during their differentiation into mature osteoclasts. Denosumab has a high affinity with RANKL, preventing RANK ligand from activating RANK on the surface of osteoclasts, inhibiting osteoclast activation and development, reducing bone resorption, increasing bone density and bone strength of both cortical bone and trabecular bone, promoting bone reconstruction, and reducing the incidence of vertebral, non-vertebral and hip fractures in postmenopausal osteoporotic women.

The effect of denosumab on bone reconstruction can be evaluated by measuring some bone renewal markers, such as the bone resorption marker N-telopeptide, the bone formation marker bone-specific alkaline phosphatase, etc. A phase I clinical study conducted in healthy postmenopausal women showed that a dose-dependent decrease in morning urine NTX levels was observed on day 2 after administration. This decrease lasted for 6 months, with the maximum decrease reaching 84% compared with baseline. This effect is reversible. When serum denosumab levels disappear, NTX levels can be seen to rise again, which reflects the reversibility of its effect on bone reconstruction. As treatment continues, these effects will persist for a new cycle.

  Many patients ask how much a box of denosumab costs in China. According to the editor of Medical Travel, the specification of denosumab in the United States is 60mg/1ml tube/box and the price is US$1,169.98. It is relatively expensive and cannot be afforded by most patient families with average economic levels. In order to reduce medical expenses, most patients choose to buy Amgen’s original drug denosumab, which is launched in Turkey. The price is relatively cheap. It is currently the most cost-effective drug in the world and the one that patients buy the most. The Turkish denosumab specification is 125mg/1ml tube/box, and the price is equivalent to RMB 3,000.

Ways to purchase denosumab in Türkiye: First, you can go to Türkiye in person, but this is time-consuming, laborious, and troublesome. The most important thing is that there are unscrupulous merchants in the Turkish denosumab market and it is extremely easy to be deceived. Another method that has attracted great attention from patients is to choose a reliable overseas medical service institution, obtain regular Turkish hospital drug purchase channels, and purchase genuine products directly.