地诺单抗效果如何？

Drugs suitable for the treatment of bone metastasis, denosumab and bisphosphonates are two drugs that must be mentioned in the treatment of cancer bone metastasis. Like bisphosphonates, denosumab can reduce complications related to bone metastasis and prevent fractures; unlike bisphosphonates, denosumab targets a different protein receptor.

Bone metastasis is one of the most common metastasis sites of cancer and is widely found in many cancer types such as breast cancer, lung cancer, prostate cancer, and uterine cancer. Generally speaking, if bone metastasis occurs, cancer patients often experience severe pain and nerve damage due to changes in bone structure. Of course, some patients may experience symptoms such as leg weakness, hypercalcemia, low blood cell counts, and anemia. If bone metastases occur, patients can choose a variety of treatments such as analgesics, radiotherapy, surgery, bisphosphonates, denosumab, radionuclide therapy, and alternative therapies represented by acupuncture to relieve the pain caused by bone metastases and related complications.

Denosumab (Xgeva) was first approved in the United States in 2010 for the prevention of skeletal-related events in adults with bone metastases from solid tumors. It was also approved in Europe in 2011 for the same indication. As medical research advances, the U.S. Food and Drug Administration (FDA) has approved an expansion of its denosumab for the treatment of giant cell tumor of bone (GCTB) in adults and certain adolescents, making it the first drug to treat this rare disease in the United States. To this end, denosumab will provide a much-needed treatment option for patients who are inoperable or who would otherwise have to undergo extensive, life-altering surgery.

How effective is it? Trials have shown that denosumab has a good therapeutic effect on breast cancer bone metastasis and prostate cancer bone metastasis. In addition, denosumab is also believed to have certain anti-tumor properties. Common side effects of denosumab include weakness, nausea, and diarrhea. The above is about the effect of denosumab in the treatment of bone metastasis. To learn more, you can consult Medical Companion Travel.