Naldemedine(纳地美定)使用注意事项有哪些？

Precautions for using Naldemedine

Constipation caused by opioids is a common side effect during the treatment of this type of drug. Naldemedine can significantly improve constipation caused by opioids and shows good tolerance. It was developed by Japan's Shionogi Pharmaceutical Co., Ltd. Naldemedine was approved by the US FDA in 2017 for the treatment of chronic non-cancer pain in adult patients with opioid-induced constipation (OIC).

Things to note when using Naldemedine:

Naldemedine can cause gastrointestinal perforation. Patients should be monitored when taking the drug. If the patient develops severe, persistent or worsening abdominal pain symptoms, the drug must be stopped in time and treated under the guidance of a doctor.

Naldemedine can cause opioid withdrawal symptoms. Patients with a disrupted blood-brain barrier may be at increased risk of opioid withdrawal or reduced analgesic effects, and patients should be monitored.

Gastrointestinal-related adverse reactions increase in a dose-dependent manner, including abdominal pain, diarrhea and nausea, which means that as the drug dose increases, the adverse reactions will aggravate, and Naldemedine needs to be taken according to the dosage.

It is contraindicated in patients with known or suspected gastrointestinal obstruction, patients with an increased risk of recurrence of obstruction due to underlying gastrointestinal perforation, and patients with a history of hypersensitivity reactions to naldimedine.

Naldemedine is mainly used for patients suffering from constipation caused by opioids to solve the constipation condition without affecting the analgesic effect of cancer patients. It is a once-daily oral drug that can improve the quality of life of cancer patients. It has been marketed in Europe, the United States and Taiwan, China. It mainly acts on peripheral mu opioid receptors and plays an antagonistic role. It is recommended that patients take medication under the guidance of a doctor and receive symptomatic treatment.

Naldimedine side effects

Common side effects of naldimedine include sweating, chills, tearing, fever, cold sensation, facial warmth or hot sensation (flushing), sneezing, abdominal pain, diarrhea, nausea, vomiting, gastric or intestinal wall tear (perforation), etc. The patient's physique and condition are different, and the adverse reactions after taking the drug are also different.

Management of side effects of naldimedine

Since these adverse reactions of naldimedine are relatively serious, you should stop using naldimedine immediately and seek emergency medical help.

At the same time, it is important to note that these symptoms may also occur during the withdrawal process from opioids. Therefore, before starting to use naldimedine, the doctor should be informed of all medication history, including the use of opioids. If these symptoms occur during use, you should stop using it immediately and seek medical advice.

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