莱博雷生是最好的失眠药吗？

The effect of treating insomnia is very good.

The results of a recent network meta-analysis showed that at the recommended dose, compared with Suvorexant, benzodiazepine receptor agonists, ramelteon, and trazodone, Lemborexant had the best improvement effect on total sleep time (TST), sustained sleep latency (LPS), and SE in the objective measurement results of polysomnography at 4 weeks, and its improvement effect on awakening after sleep onset (WASO) was second only to Suvorexant.

About Lemborexant

Lemborexant belongs to DORAs and was approved in the United States in December 2019 and in Japan in January 2020. It is used to treat adult patients with insomnia mainly characterized by difficulty falling or staying asleep.

It is understood that the first prescription of Laibo Leisheng Tablets (Daweimian) was issued at Guangzhou United Family Hospital on January 16, 2023. This is an innovative drug launched in the Greater Bay Area under the "Hong Kong and Macao Drug-Device Access" policy, which will give insomnia patients more treatment options.

Effects of Leborexant

1. Competitive antagonism: Lemborexant can competitively antagonize orexin receptor 1 and orexin receptor 2 at the same time.

2. Inhibiting the wake-promoting effect of orexin: By antagonizing these two orexin receptors, Lemborexant can inhibit the wake-promoting effect of orexin.

3. Treatment of insomnia: By inhibiting the occurrence of arousal, Lemborexant plays an important role in improving insomnia symptoms.

Efficacy of lemborexant

Moline et al. analyzed data from 9 clinical trials and evaluated the residual effects of lemborexant on the next day, including effects on physical stability, cognitive ability, driving function, subjective drowsiness and drowsiness in the early morning.

The results showed that compared with the placebo group, lemborexant did not significantly affect functional performance during the next day, and after up to 6 months of treatment, patients using lemborexant were more alert the next morning; the incidence of sleepiness in patients taking lemborexant 5mg was 8.6%, which was slightly higher than suvorexant.

A retrospective study on the Japanese population showed that when the drug was discontinued after 6 months of continuous use, uncomfortable symptoms caused by drowsiness, fatigue and nightmares could resolve themselves, which may be related to the long half-life of the drug.

Usage and Dosage of Leborexen

1. Recommended dose: The recommended dose of Leborexen is 5 mg taken before going to bed every night, no more than once.

2. Taking time: At least 7 hours remain before the planned awakening time to ensure that the drug takes full effect and avoid residual effects the next day.

3. Dose adjustment: Based on clinical response and tolerance, the dose can be gradually increased to the maximum recommended dose of 10 mg.

4. How to take it: It is not recommended to take it with a meal or shortly after a meal, as this may cause a delay in falling asleep.

The above information comes from the US FDA instructions. Patients need to follow the doctor's instructions and use the medicine correctly when actually using it.

For more information about leborexine, please refer to:

Side effects of leborexine

The most common side effect of leborexine is drowsiness. The following are treatment measures:

1. Adjust the medication time: Make sure to take leborexine before bed, and try to ensure enough sleep time after taking the drug to reduce the possibility of daytime drowsiness.

2. Avoid high-risk activities: After taking Lebraxant, especially during the peak period of drug effects, you should avoid driving vehicles, operating machinery, or other activities that require high concentration and quick reaction.

3. Regular work and rest time: Maintaining a regular work and rest time will help the body adapt to the effects of the drug and reduce the occurrence of drowsiness.

4. Communicate with your doctor: If the symptoms of drowsiness are severe or continue to affect your normal life, you should communicate with your doctor in time. The dosage of the drug may need to be adjusted or other treatment options may need to be changed.

5. Avoid drinking alcohol: You should avoid drinking alcohol while taking leborexan, because alcohol may increase the risk of drowsiness.

6. Observe other side effects: Drowsiness may be a common side effect of leborexan, but it may also occur at the same time as other side effects. Therefore, patients should carefully observe their own conditions and seek medical attention promptly if they have any abnormal reactions.

Following the above treatment measures will help reduce the symptoms of drowsiness caused by Leborexen and improve the patient's quality of life. At the same time, patients are also advised to read the instructions carefully and follow the doctor's advice before taking any medicine.

Recommended hot articles: