Can Leborex completely cure insomnia?

Insomnia cannot be completely cured

Insomnia is a common disorder associated with a substantial disease burden, especially among older adults. Leborexant is an orexin receptor antagonist similar to suvorexant and has been approved for the treatment of sleep-related and/or maintenance insomnia. After patients use it, it can improve insomnia symptoms and relieve symptoms such as difficulty falling asleep and maintaining sleep, but it cannot completely cure insomnia.

Leborexen is rapidly absorbed (peak 1-3 hours), has a half-life of 17-19 hours (half-life 12 hours), is metabolized by CYP3A4/5, and has no significant influence on age, gender, or body weight. Insomnia trials have shown sustained efficacy for more than 6 months.

Leborexen drug introduction

Leborexan is an oral dual orexin receptor (OXR) antagonist that exhibits a reversible competitive antagonist on OXR1 and OXR2. It is an OXR2 affinity protein discovered and developed by Eisai for the treatment of adult patients with insomnia. It was first approved in the United States in December 2019 for the treatment of adult patients with insomnia characterized by sleep onset and/or difficulty maintaining sleep. It was approved in Japan for the treatment of insomnia in January 2020. It is also used to treat irregular sleep-wake rhythm disorder (ISWRD) associated with mild to moderate Alzheimer's disease.

One trial showed that treatment with leborexan resulted in a significant increase in total sleep time from baseline compared with placebo and zolpidem. Compared with placebo and zolpidem, leborexan produced a significant increase in REM sleep latency from baseline and a significant decrease in REM sleep latency from baseline.

Additionally, Leborexen may be a better treatment option for insomnia than other pharmacological treatments because it is effective over the long term and across a wide range of outcome measures. Importantly, Leborex improves sleep onset and sleep maintenance latencies, helping those who experience early morning awakenings.

Taken together, lemborexant is a new, effective, and well-tolerated insomnia medication that may address some of the sleep architecture changes commonly observed in older patients with insomnia.

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