罗氟司特使用说明书

[Drug name] Roflumilast, Roflumilast film tablets, tablets, roflumilast, Daxas, Daliresp

[Indications] Chronic obstructive pulmonary disease (COPD)

[Mechanism of action] Roflumilast is a long-acting inhibitor of selective phosphodiesterase type 4 (PDE-4) and has anti-inflammatory effects. Phosphodiesterases are a family of enzymes including at least 11 subtypes of enzymes that catalyze the decomposition of the messenger molecules cyclic adenosine monophosphate and/or cyclic guanosine monophosphate. Phosphodiesterase-4 is a major cyclic adenosine monophosphate metabolic enzyme in inflammatory and immune cells, and phosphodiesterase-4 inhibitors have broad anti-inflammatory activities including inhibiting the release of inflammatory mediators and inhibiting immune cell activation. In addition, phosphodiesterase-4 inhibitors have also been shown to have therapeutic effects in animal models of airway inflammation.

[Recommended dose] The recommended dose for patients with COPD is 500 mcg once daily, with or without food.

[Adverse Reactions] The most common adverse reactions (≥2%): diarrhea, weight loss, nausea, headache, back pain, influenza, insomnia, dizziness and decreased appetite.

[Contraindications] Moderate to severe hepatic impairment (Child-Pugh classification B or C)

[Storage] Keep away from light and sealed.

【Notes】

Acute bronchospasm: Do not use to relieve acute bronchospasm.

Psychiatric events including suicidal behavior: Advise patients, their caregivers, and families to be alert to the emergence or worsening of insomnia, anxiety, depression, suicidal thoughts, or other mood changes, and to contact their health care provider if such changes occur. Carefully weigh the risks and benefits of treatment with DALIRESP in patients with a history of depression and/or suicidal thoughts or behaviors.

Weight Loss: Monitor your weight regularly. If unexplained or clinically significant weight loss occurs, evaluate weight loss and consider discontinuing use.

Drug Interactions: Use with strong cytochrome P450 enzyme inducers (eg, rifampicin, phenobarbital, carbamazepine, phenytoin) is not recommended.

The above instructions are instructions. Please use the medicine correctly under the guidance of a doctor.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.