能倍乐 思力华噻托溴铵的效果怎么样

How effective is Tiotropium bromide? Respimat Tiotropium is a long-acting anticholinergic drug with similar affinity for the five choline receptors (M1-M5). It dilates bronchial smooth muscle by binding to M3 receptors on smooth muscle. This effect is competitive and reversible. In vivo and in vitro studies have shown that Respimat has a dose-dependent and sustainable 24-hour inhibition of methacholine-induced bronchoconstriction. Respimat's bronchial dilation effect has outstanding localization selectivity.

Chronic obstructive pulmonary disease is a type of chronic bronchitis and/or emphysema characterized by airflow obstruction, which can further develop into common chronic diseases such as cor pulmonale and respiratory failure. It is related to the abnormal inflammatory response of harmful gases and harmful particles, resulting in high disability and mortality rates. The launch of Respimat has brought new hope for the treatment of COPD patients.

The effect of Tiotropium Bromide lasts for 24 hours, which means it only needs to be used once a day, preferably at the same time every day. Spray twice with each use. It should be noted that patients should not overdose to avoid harm to the body.

The approval of Respimat was based on data from two pivotal Phase III trials (TONADO-1, -2). The study involved more than 5,000 COPD patients. Data showed that compared with placebo, tiotropium bromide, and olodaterol monotherapy, Respimat produced a statistically significant improvement in patients' lung function (FEV1) and had a similar safety profile to tiotropium bromide or olodaterol.

The use of Tiotropium Bromide helps open the airways, making it easier for air to move in and out of the lungs. Normal use of Respimat can also relieve persistent shortness of breath caused by the disease, helping to minimize the impact of the disease on daily life.

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