多少钱可以买到他克莫司胶囊(ASTAGRAFXL)

Tacrolimus capsule is clinically used as an immunosuppressant to prevent rejection after kidney transplantation. It reduces the risk of organ rejection by inhibiting T cell activity. Patients must strictly follow the doctor's prescription to ensure the function of the transplanted organ.

How much can I buy Tacrolimus Capsules (ASTAGRAFXL)

Tacrolimus Capsules have been launched in China and have been included in the scope of medical insurance reimbursement in China. When purchasing medicines, you must look for formal channels and avoid purchasing products from unknown sources.

Specifications and Prices

The original drug produced by Japan's Towa Pharmaceutical has a specification of 0.5mg*100 tablets and a price of about US$110 per box. The reimbursement rate for medical insurance varies depending on regional policies. Patients need to bring their transplant medical records and doctor's prescriptions to purchase drugs.

Why original drugs are expensive

Original drugs have a long research and development cycle, requiring billions of dollars to be invested in clinical trials and safety verification, as well as customs duties and warehousing costs. Because generic drugs eliminate the need for research and development, production costs are significantly reduced. However, when purchasing, you need to choose products that have passed consistency evaluation to ensure that the efficacy is equivalent to that of the original drug.

It is recommended that patients purchase drugs through hospital pharmacies or authorized online platforms, and keep the outer packaging and invoices after purchasing to facilitate subsequent medical insurance reimbursement.

Tacrolimus Capsules (ASTAGRAFXL) Precautions

The therapeutic window of tacrolimus is narrow. If the blood concentration is too high, it may cause toxic reactions, and if it is too low, it will increase the risk of rejection. The following matters require special attention:

Necessary examinations before medication

Liver and kidney function, blood routine and electrocardiogram examinations must be completed before treatment. Patients who carry the ApoEε4 gene or have cerebral microbleeds need additional evaluation for the risk of neurotoxicity. If you have recently received a live vaccine, you need to delay the administration for at least 4 weeks.

Dietary and drug taboos

It is forbidden to eat grapefruit, star fruit and alcohol while taking the medicine. These foods will inhibit the activity of liver enzyme CYP3A4 and lead to an increase in blood drug concentration. Avoid combination with strong CYP3A4 inhibitors or inducers. If necessary, adjust the dose and increase the frequency of blood concentration monitoring.

Pregnant women must strictly use contraception. If they become pregnant unexpectedly, they must stop taking the medicine immediately and seek medical treatment. Breastfeeding women should suspend breastfeeding. Pediatric patients (≥4 years old) need to accurately calculate the dose based on body weight to ensure that the entire capsule can be swallowed.

If you experience hand tremors, blurred vision, or reduced urine output, you need to contact your doctor immediately to adjust your treatment plan.

Daily care for kidney transplant patients

Long-term maintenance of immunosuppressive therapy is required after kidney transplantation. Scientific daily care can reduce the risk of complications and improve the quality of life.

Diet management and nutritional support

Daily protein intake is controlled at 0.8-1.0g/kg, mainly high-quality protein (such as fish, eggs). Limit the intake of high-potassium foods (such as bananas and potatoes) to prevent hyperkalemia.

Use olive oil instead of animal oil when cooking to reduce cardiovascular burden. Drink 1500-2000mL of water every day and avoid drinking unboiled water.

Infection prevention measures

Avoid going to crowded places and wear a mask when going out. The home environment is regularly ventilated and disinfected, and tableware is sterilized at high temperatures every day. If you have fever, cough, or wound redness and swelling, you need to seek medical attention immediately to check for infection. Inactivated influenza vaccine is given annually, but live attenuated influenza vaccine is prohibited.

Psychological support and rehabilitation training

Anxiety or depression may easily occur after surgery, and family members need to listen patiently and provide encouragement. You can join a support group for kidney transplant patients to share recovery experiences. Perform 30 minutes of low-intensity exercise (such as walking, Tai Chi) every day to enhance immunity. Avoid heavy lifting or strenuous exercise to prevent pressure on the transplanted kidney.

In daily care, blood pressure, urine output and weight changes need to be recorded every day, and provided to the doctor for reference during follow-up visits. Medications need to be stored away from light below 25°C to avoid deterioration due to moisture.