甲磺酸贝舒地尔片的正确购买途径

Introduction: Belumosudil mesylate tablets (Belumosudil) is an investigational oral Rho-associated coiled-coil protein kinase 2 (ROCK2) selective inhibitor. It reduces type 17 and follicular T helper cells by down-regulating STAT3, and enhances regulatory T cells by up-regulating STAT5.

Besudil mesylate tablets can effectively treat patients with chronic graft-versus-host disease (cGVHD), which is the main cause of morbidity and late non-relapse death after allogeneic hematopoietic cell transplantation.

The correct way to purchase generic drugs of Besudil Mesylate Tablets

Generic drugs are more commonly produced by Lucius Pharmaceutical Factory in Laos. When purchasing generic drugs of Besudil Mesylate Tablets, you should make sure to purchase them through legal and formal channels to ensure the quality and safety of the drugs. The more common ones are as follows.

1. Hospital pharmacy: You can go to the country where the generic drug of Besudil Mesylate Tablets is listed and inquire whether the local hospital provides this drug.

2. Legal pharmacies: Besudil mesylate tablets may be sold in some legal large pharmacies or professional pharmacies in countries where they are listed. Patients can find several regular pharmacies for consultation and purchase.

3. Medical service institutions: Domestic patients can also purchase Besudil mesylate tablets through medical service institutions. After purchase, they usually obtain the medicine through direct mail.

When purchasing generic drugs, you should ensure that they have been approved by the National Medical Products Administration and have a legal generic drug approval number. The price of generic Besudil mesylate tablets produced by Lucius is about 4050$-4600$ per box. The price is for reference only, and the actual price shall prevail.

Therapeutic Efficacy of Besudil Mesylate Tablets

A phase 2 randomized multicenter registration study evaluated the effects of besudil mesylate tablets 200 mg daily (n=66) and 200 mg twice daily (n=66) in patients with cGVHD who had received 2-5 prior therapies. The primary endpoint was best overall response rate (ORR), with duration of response (DOR), change in Lee symptom scale score, failure-free survival, corticosteroid dose reduction, and overall survival also assessed.

The overall median follow-up period was 14 months. The best ORRs of besudil mesylate tablets 200 mg daily and 200 mg twice daily were 74% and 77%, respectively. High response rates were observed in all subgroups. All affected organs showed a complete response. The median DOR was 54 weeks, and 44% of subjects continued treatment for ≥1 year. Symptom reduction was reported by 59% and 62% of subjects taking besudil mesylate tablets 200 mg daily and 200 mg twice daily, respectively.

How to store and handle Besudil mesylate tablets

1. Besudil mesylate tablets should be stored in the original packaging, sealed and kept out of the reach of children. Store it at room temperature (20°C-25°C, the allowed fluctuation range is 15°C-30°C), away from overheated and humid places, and do not remove the desiccant.

2. It is important to keep the medicine out of the sight or reach of children. In order to protect children from poisoning, it is recommended to always lock the safety cover and immediately put the medicine in a safe place, away from the sight of children.

Besudil mesylate tablets may cause a series of side effects. If you have any abnormal problems while taking this medicine, please seek medical attention immediately.