The efficacy and function of Pulekefu

Tacrolimus is an immunosuppressant. In clinical medicine, Tacrolimus is used to prevent allograft rejection after liver transplantation (including liver, kidney, heart and pancreas) and diseases that require immunosuppressive treatment, such as lupus nephritis, membranous nephropathy, focal segmental tubular sclerosis and subtle lesions. What are its functions and functions?

The efficacy and function of Pulekefu

Tacrolimus is used to prevent graft rejection after liver and kidney transplantation and to treat graft rejection that cannot be controlled by other immunosuppressive drugs after liver and kidney transplantation. At the molecular level, Tacrolimus uses it to combine with cellular proteins, thereby accumulating and functioning in cells. The combined complex inhibits the calcium ion-dependent information transduction pathway produced by T cells, thus preventing the transcription of discontinuous lymphokine genes.

Tacrolimus is a highly immunosuppressive drug, and its activity has been confirmed in in vitro and in vivo experiments. Tacrolimus exerts its efficacy by inhibiting the production of cytotoxic lymphocytes, which are the main cause of transplant rejection, and inhibiting the activation of T cells and the proliferation of T helper cell-dependent B cells.

The immunosuppressive effect of Tacrolimus is tens to hundreds of times that of cyclosporine in both in vitro and in vivo tests. Clinically, Tacrolimus is effective at a concentration of 1%. In addition, Tacrolimus is better than cyclosporine in inhibiting rejection reactions that have already occurred.

The above is the introduction about Tacrolimus. If patients want to know more about the drug information of Tacrolimus, they can consult the medical companion travel service.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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