Can I use Preclosumab after lung transplantation? Therapeutic effect of Pulekefu

Plexif, also called tacrolimus capsules, is indicated for the prevention of graft rejection after liver or kidney transplantation. Treatment of graft rejection that cannot be controlled by other immunosuppressive drugs after liver or kidney transplantation. In other words, Precox can be used after lung transplantation. Today let’s learn about the effects of using Precore.

The immunosuppressive effect of Preclosumab is tens to hundreds of times that of cyclosporine in both in vitro and in vivo tests. Clinically, a concentration of 1% of Preclosumab is effective. In addition, Preclosumab is better than cyclosporine in inhibiting rejection reactions that have already occurred. In the past immunosuppressive regimens based on cyclosporine, the problem of irreversible chronic rejection remained the same. Although increasing the dose had further effects, it also brought serious adverse reactions. Preclosumab is expected to reduce acute and chronic rejection in liver and kidney transplant recipients.

The bacterial and viral infection rate of patients taking Proclospora is also lower than that of patients treated with cyclosporine. In particular, this product has strong hepatotropic properties and is 100 times more effective in liver transplantation. Therefore, the clinical dosage is greatly reduced, and the original treatment cost can be reduced by 1/3 to 1/2 ( Because patients who use this product can be discharged from the hospital 2 weeks after surgery (while those who use cyclosporine need 4 weeks), and adverse reactions are also significantly reduced, Preclosumab has the advantages of low mortality, high transplant survival rate, good graft success rate, and relative independence from steroids.

Proclofu is widely used in organ transplantation (kidney transplantation, liver transplantation, heart transplantation, lung transplantation and stem cell transplantation, etc.), as well as in autoimmune diseases, kidney diseases and blood system diseases.

It should be noted that Preclosumab cannot be used in combination with cyclosporine. Preclosumab has been associated with visual and neurological disorders. Therefore, patients who have taken Proximax and have experienced the above-mentioned adverse effects should not drive or operate dangerous machinery. This effect may be worsened by drinking alcohol.

When the blood concentration of paclitaxel and tacrolimus is maintained below 20 mg/mL, the condition of most patients can be successfully controlled. The patient's clinical condition must be considered when measuring whole blood concentrations. If the blood concentration is below the limit of quantification that can be measured by quantitative analysis and the patient's clinical condition is good, no dosage adjustment is necessary. In clinical use, the whole blood trough concentration of this drug is usually 5-20 mg/mL in the first 12 hours after transplantation.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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