赛洛多辛(Silodosin)的功效与作用

Silodosin was developed by Kissei Pharmaceutical Co., Ltd. and was first launched in Japan in 2006 under the Urief brand.

Efficacy and effects of Silodosin

It is a selective postsynaptic α-1 adrenergic receptor antagonist. These receptors are found in the human prostate, bladder base, bladder neck, prostate capsule and prostatic urethra.

Blocking these alpha-1 adrenergic receptors causes the smooth muscles in these tissues to relax, thereby improving urinary flow rate and reducing BPH symptoms.

Silodosin (Silodosin) Indications and Applicable Populations

1. Indications

Silodosin is suitable for urinary disorders caused by benign prostatic hyperplasia (BPH), such as difficulty urinating, thin urine lines, frequent urination, urgency, increased nocturia and other symptoms.

2. Applicable population

Adult male patients: men diagnosed with BPH and accompanied by urinary disorders.

The pictures are from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Silodosin usage and dosage

1. Conventional dosage

Adults take 4 mg orally (calculated as Silodosin) twice a day.

2. How to take the medicine

It is recommended to take it after breakfast and dinner to reduce gastrointestinal discomfort.

3. Usage of OD tablets

It can be placed on the tongue, disintegrated with saliva and then swallowed. It can also be taken with water; however, it needs to be taken with water when lying in bed.

4. How to take medication for patients with dysphagia

Patients who have difficulty swallowing tablets or capsules can carefully open the silodosin capsule and sprinkle the contained powder on a tablespoon of applesauce. Applesauce should be swallowed immediately (within 5 minutes) without chewing, followed by drinking 8 ounces of cool water to ensure complete swallowing of the powder.

Applesauce should not be hot and should be soft enough to swallow without chewing. Any powder/applesauce mixture should be used immediately (within 5 minutes) and should not be stored for later use.

5. Dose adjustment

(1) Renal insufficiency: Silodosin capsules are contraindicated in patients with severe renal insufficiency (creatinine clearance CCr<30mL/min).

In patients with moderate renal insufficiency, the dose should be reduced to 4 mg once daily with food.

For patients with mild renal insufficiency, there is no need to adjust the dose of the drug.

(2) Hepatic insufficiency: Silodosin capsules have not been studied in patients with severe hepatic insufficiency and are therefore contraindicated for use in such patients.

In patients with mild or moderate hepatic impairment, dose adjustment is usually not required.