赛洛多辛(Silodosin)会引起什么副作用

With the highly selective antagonism of α1A-adrenergic, silodosin can significantly improve the symptoms of lower urinary tract obstruction and dysuria in patients with benign prostatic hyperplasia, mainly through the relaxation of the smooth muscles of the prostate and bladder neck, which significantly improves urinary flow.

What side effects does Silodosin cause?

Retrograde ejaculation

Patients may experience retrograde ejaculation after taking Silodosin, that is, semen flows into the bladder instead of being discharged through the urethra.

Such side effects are relatively easy to reverse after stopping the drug, and they generally return to normal quickly after stopping the drug. Patients can first reach a consensus with their doctor about the existence of this possible side effect and explore alternative treatment options that may be more satisfactory to them.

Dizziness and Orthostatic Hypotension

Silodoxin may cause dizziness or orthostatic hypotension, especially when getting up or standing.

Patients should try to avoid standing up suddenly, and instead slowly change their body position from lying to sitting, standing, etc., to reduce the tendency of blood in the body to pool towards the head and reduce the factors causing dizziness, thereby achieving the purpose of preventing dizziness.

The pictures are from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Nasal congestion and runny nose

Some patients will develop cold-like symptoms such as nasal congestion and runny nose.

These symptoms are usually mild. Keeping the nasal cavity moist and using saline nasal spray can relieve discomfort. If the symptoms seriously affect your life, you can consult your doctor for symptomatic treatment.

Diarrhea and gastrointestinal discomfort

A small number of patients may experience indigestive adverse reactions such as mild diarrhea, periumbilical or whole-abdominal discomfort.

Patients can drink lightly salted water after meals, which can not only reduce the acidity in the stomach to a certain extent, but also maintain sufficient water intake, which has a good effect on reducing gastrointestinal irritation. However, if diarrhea persists or worsens, you should contact your doctor promptly to evaluate whether the original medication regimen needs to be adjusted accordingly.

Reduced ejaculation volume

Some patients may experience a significant reduction in ejaculation volume.

Most patients can recover quickly after stopping the drug. Patients do not need to worry too much, but if they are bothered by this, they can talk to their doctor about other treatment options.

Allergic reactions

Individual patients may experience adverse side effects such as rash, itching, etc. due to special allergic reactions to drugs.

But for mild allergic reactions, doctors usually prescribe some symptomatic antihistamine drugs or topical topical corticosteroids, which can better control the allergic reaction. Severe allergic reactions are rare but require emergency treatment.

What are the special medication groups for Silodosin?

Elderly patients

As the elderly, the body will undergo a series of physiological changes with age, and will also become more sensitive to the drugs they take. Although there is no need to adjust the dosage, additional attention is also required.

Based on the actual body response, you can start with a lower dose and gradually adjust it to an appropriate therapeutic dose for blood pressure.

Patients with hepatic insufficiency

Patients with mild hepatic insufficiency can still be treated with conventional drug doses, but their liver function indicators should be monitored regularly.

However, due to the complex effects of silodosin on liver metabolism, patients with moderate to severe liver damage should not use it. It can easily cause drug metabolism disorders and aggravate its easy side effects.

People with renal insufficiency

For patients with mild renal insufficiency, standard drug dosages can also be used, but changes in blood drug concentrations should be monitored at any time. Caution should be used in patients with moderate renal insufficiency, and the starting dose is recommended to be halved.

However, for patients with severe renal insufficiency or those who are about to require dialysis, the clearance and metabolism of the drug may be significantly reduced, which may accumulate in the blood to harmful higher doses, resulting in more serious adverse reactions or even poisoning, so silodosin should be banned.

Patients taking other medications at the same time

Patients should inform their doctor of all medications they are taking, including prescription and over-the-counter medications.

Patients planning surgery

Patients planning to undergo cataract surgery or other eye surgery must inform the surgeon in advance that they are taking silodosin.

To reduce the risk of iris flaccidity syndrome during surgery, you may need to temporarily stop taking certain long-term medications before surgery.

How to store Silodosin

Storage temperature requirements

Silodosin should be stored at room temperature between 20°C and 25°C. The temperature can be allowed to fluctuate between 15°C and 30°C when taken out for a short period of time.

Avoid placing medicines in places with high humidity, such as bathrooms or kitchens, and do not place them in places where the temperature is likely to rise, such as inside car windows.

Light protection measures

To avoid reducing the effectiveness of the medicine due to long-term exposure to light, stored tablets should be placed in the original packaging. Store the original packaging in a cool and ventilated place away from direct sunlight, which can not only ensure the effectiveness of the medicine but also extend its storage period.

If the original packaging is damaged, it should be stored in a new light-proof container.

Moisture-proof treatment

Be sure to close the bottle cap tightly immediately after taking the medicine to ensure that the medicine container is always sealed.

Child-safe storage

All medications must be kept out of the reach and sight of children. Locked medicine cabinets or overhead storage shelves are recommended.