非那雄胺可用于治疗什么病症？

What conditions can it be used to treat? Finasteride is a drug approved for use in 1992 and is mainly used to treat prostatic hyperplasia. Later, in 1997, the U.S. Food and Drug Administration approved the drug for the treatment of male pattern baldness.

Finasteride is a 5α-reductase inhibitor. It is a specific inhibitor of the intracellular enzyme type II 5α-reductase during the metabolism of the androgen testosterone into dihydrotestosterone. By inhibiting 5-alpha reductase, finasteride prevents the conversion of testosterone to dihydrotestosterone (DHT), reducing DHT levels in the serum.

By blocking the production of DHT, finasteride reduces androgen activity in the scalp. Men who are congenitally deficient in type II 5α-reductase do not suffer from male pattern baldness. These data and the results of clinical studies confirm that finasteride can inhibit the reduction of scalp hair follicles and reverse the process of hair loss.

The inhibitory effect of 5α reductase is stronger in epithelial cells than in stromal cells. Clinical studies have found that BPH patients who took finasteride (5 mg·d -1) orally for 6 years reduced prostate volume by 20% to 30%, the International Prostate Symptom Score (IPSS) and residual urine volume were significantly reduced, and the maximum urinary flow rate was significantly increased, which was significantly different from the placebo group. Comparative studies with the alpha-blocker tamsulosin have shown that finasteride can significantly improve urodynamic parameters in patients with BPH, but its onset of action is slower than that of alpha-blockers. Most scholars believe that for patients with prostate volumes greater than 40 to 50 mL, with in-depth research on the pharmacological effects of finasteride, its clinical application will receive increasing attention.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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