依普利酮的使用说明

It is a new type of selective aldosterone receptor antagonist that was approved for clinical use by the State Food and Drug Administration in 2002. It has stronger aldosterone antagonism than spironolactone, and has extremely low affinity for androgen and progesterone receptors. It has few adverse reactions and has definite efficacy in the treatment of hypertension, heart failure and myocardial infarction. It has fewer adverse reactions and good tolerance. It is a good alternative to spironolactone.

Eplerenone is a new type of selective aldosterone receptor blocker that can effectively control hypertension, reduce damage to target organs such as the heart, brain and kidneys, and improve microalbuminuria in patients with type 2 diabetes. So, what are the instructions for the use of eplerenone?

1. Instructions for the use of eplerenone in congestive heart failure after acute myocardial infarction:

The recommended dose is 50mg/time, once daily;

The initial dose should be 25mg/time, once daily;

And within 4 weeks, under the conditions tolerated by the patient, gradually increase the dose to 50mg/time, once a day.

2. Instructions for use of eplerenone against hypertension:

Eplerenone can be used alone or in combination with other antihypertensive drugs. The recommended initial dose for use alone is 50 mg once daily.

Obvious pressure-reducing effect will appear within four weeks of taking the medicine. If the pressure effect is not obvious, it can be increased to 50mg/time, once a day.

Higher dosages are not recommended, otherwise there is an increased risk of adverse reactions such as hyperkalemia.

Eplerenone is a mineralocorticoid receptor antagonist that competes with aldosterone. Aldosterone receptors in late distal renal tubules and renal collecting ducts can induce sodium reabsorption and potassium excretion from the distal renal tubules. Inhibiting this receptor causes sodium ions to be excreted in the urine while maintaining potassium levels in the body. Eplerenone has a higher affinity for aldosterone receptors and is associated with less anti-adrenergic reactions (gynecomastia and alopecia) than spironolactone.

It was well tolerated, with the most common side effects including hyperkalemia and increased serum creatinine.