依普利酮的售价是多少？

Antihypertensive drugs. For severe hypertension that cannot be controlled by a combination of multiple antihypertensive drugs, the addition of eplerenone can significantly reduce blood pressure, especially the decrease in systolic blood pressure is more significant. Combined treatment with angiotensin-converting enzyme inhibitors (ACEI) and beta-blockers can improve patients' quality of life and reduce mortality in severe heart failure and myocardial infarction.

It was approved for clinical use by the State Food and Drug Administration in 2002. So, how much does eplerenone cost?

According to Medical Travel, although eplerenone can be used clinically, it has not been officially approved for marketing, and the price abroad is relatively expensive!

Therefore, what I need to tell you here is that the price of eplerenone 50mg × 100 tablets from India's Lupine Pharmaceuticals is about $500. Since exchange rates fluctuate and prices are not fixed, please consult Medical Travel for specific prices.

Eplerenone drug interactions:

Eplerenone is not an inhibitor of CYP1A2, CYP3A4, CYP2C19, CYP2C9 or CYP2D6 and does not inhibit diclofenac, methylphenidate, losartan, amiodarone, dexamethasone, phenytoin, phenacetin, dextromethorphan, metoprolol, tolbutamide, amlodipine, astemizole, cisapride, diazepam, 17- Metabolism of ethinyl estradiol, fluoxetine, lovastatin, methylprednisolone, midazolam, nifedipine, glyburide and warfarin. Ketoconazole is a strong inhibitor of CYP 3A4, which can increase the plasma concentration of eplerenone by 5 times, and should be avoided in combination with it. Drugs such as verapamil, erythromycin, and saquinavir are weak inhibitors of CYP 3A4, which can increase the plasma concentration of eplerenone by 2 times, and should be used with caution.

Precautions for eplerenone

1. Eplerenone cannot be combined with potassium supplements, potassium-containing salts or contraindicated drugs (potassium-sparing diuretics, strong inhibitors of CYP450 liver enzymes).

2. Patients with high serum potassium, type 2 diabetes patients with microalbuminuria, patients with high serum creatinine levels, and patients with muscle intoxication clearance <50mL/min should not take it. Pregnant women, children, and those with hepatic and renal insufficiency should use with caution.