用依普利酮需要注意什么呢？

It has definite efficacy in the treatment of hypertension, heart failure and myocardial infarction, has fewer adverse reactions and is well tolerated. So, what should we pay attention to when using eplerenone?

Precautions for eplerenone:

(1) Eplerenone can pass through the placenta. There are reports in the literature that the use of eplerenone in the second and third trimester of pregnancy can cause neonatal hypotension, renal failure, lung and skull dysplasia, oligohydramnios, or death. Therefore, its use should be avoided during pregnancy, and the pros and cons should be weighed when it must be used.

(2) Eplerenone can increase blood potassium and blood urea nitrogen, and combined use of potassium-sparing diuretics or renal artery stenosis can easily cause hyperkalemia.

(3) In patients with severe cerebral artery or coronary artery insufficiency, the use of eplerenone may aggravate ischemia due to lowered blood pressure; in patients with aortic valve stenosis, the use of eplerenone may reduce coronary artery perfusion; it should be contraindicated in patients with bilateral renal artery stenosis.

(4) The dosage should be individualized, especially the elderly should start with a small dose and gradually increase the dosage according to the antihypertensive effect.

(5) If hypotension occurs when eplerenone is used during anesthesia or surgery, it can be corrected by supplementing blood volume.

(6) During medication, attention should be paid to checking blood potassium, white blood cells, hemoglobin, blood urea nitrogen and transaminases.

(7) People who are allergic to eplerenone or other ACEI should not take this product.

(8) Liver damage: Use with caution in patients with moderate to severe liver damage. 

(9) Kidney damage: As kidney function declines, the risk of hyperkalemia increases. Use with caution in patients with mild renal impairment; it may be disabled depending on the indications and degree of damage. 

(10) Drug-Drug Interactions: Significant interactions may exist requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapies.

(11) Pregnancy: Untreated hypertension and heart failure are both associated with adverse pregnancy outcomes. The use of mineralocorticoid receptor antagonists is not recommended for the treatment of chronic isolated hypertension in pregnant women and should generally be avoided in women of reproductive potential.

The above is the relevant content about precautions!