Planep作用效果

For congestive heart failure after acute myocardial infarction; for the treatment of hypertension.

Aldosterone is an important component present in the renin-angiotensin-aldosterone system (RAAS) and plays an important role in the regulation of the human cardiovascular system. According to the "American Journal of Hypertension", Planep, a selective aldosterone receptor blockade, can effectively control mild to moderate hypertension and is well tolerated. Studies have shown that Planep can cause sustained increases in plasma renin and serum aldosterone, and at the same time block the feedback regulatory effect of aldosterone. However, the increase in plasma renin activity and the increase in systemic circulation aldosterone levels will not offset Planep's control effect on blood pressure. Planep and spironolactone work on the same principle. Long-term use of spironolactone can cause endocrine disorders, while Planep has the advantages of good tolerance and few side effects, avoiding the side effects of endocrine disorders.

Planep selectively acts on aldosterone receptors, is highly selective for mineralocorticoid receptors, and has less effect on androgen and progesterone receptors. Its affinity for mineralocorticoids is 15 to 20 times that of spironolactone, and its affinity for androgen and progesterone receptors is 500 times smaller than that of spironolactone, so it is less likely to cause adverse reactions related to sex hormones. Planep treats patients with stage 1 and stage 2 hypertension, and its effectiveness and reduction in systolic and diastolic blood pressure are similar to those of enalapril. Planep also has a good antihypertensive effect in patients with essential hypertension with low renin levels for whom angiotensin-converting enzyme inhibitors and angiotensin II receptor inhibitors are ineffective. It also has a good antihypertensive effect on simple systolic hypertension, and has a good antihypertensive effect on diet-induced obesity-related hypertension. In addition, it can significantly reduce the ultrafiltration effect of glomeruli and reduce albuminuria in patients with hypertension. This renal protective effect is more obvious for patients with hypertension combined with diabetes.