利特昔替尼在中国上市了吗?好购买吗？

Introduction: Ritlecitnib is a selective dual Janus kinase 3 (JAK3) and tyrosine protein (TEC) kinase inhibitor that has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of adults and adolescents 12 years and older with severe alopecia areata (AA).

Is ritexitinib available in China?

It is already available in China. On October 19, 2023, the State Food and Drug Administration approved the launch of the Class 1 innovative drug Ritexitinib Tosylate Capsules (trade name: Rofenox) applied by Pfizer through the priority review process. It is suitable for adolescents and adult patients with severe alopecia areata aged 12 years and above. This marks the official approval of Ritexitinib in China and provides a new treatment option for eligible patients.

The FDA approved ritixitinib for the treatment of alopecia areata on June 23, 2023, and ritixitinib was approved for marketing in Japan on June 26, 2023.

Is ritexitinib easy to buy?

Ritexitinib is already on the market in China and can be purchased through a variety of channels. Here are a few.

1. Hospital pharmacy: Patients can go to the dermatology department of the hospital for treatment. After a professional doctor issues a prescription, they can purchase it directly in the hospital pharmacy.

2. Physical pharmacies: After obtaining a doctor’s prescription, patients can go to regular pharmacies to purchase ritexitinib.

3. Online pharmacies: Some regular online pharmacies may provide ritexitinib purchase services, but before purchasing the drug, you should choose an online pharmacy with a good reputation and a formal business license.

4. Pfizer’s official website: You can visit Pfizer’s official website to see if there is information on drug purchase or information on partner pharmacies.

5. Purchase abroad: If you want to buy generic ritexitinib, you can go to the country where generic drugs are listed. If you want to buy the overseas original version of ritexitinib, you can go directly to the United States to buy it.

The mechanism of action of ritexitinib

Alopecia areata involves an attack by the immune system on hair follicles, disrupting the hair growth cycle and causing hair loss. Signaling molecules, cytokines, cause this attack through pathways that exploit members of the Janus kinase (JAK) family of protein messengers in cells. Small molecules called JAK inhibitors block the activity of immune signaling pathways by binding to proteins involved in attacking hair follicles in alopecia areata. Riterxitinib is a selective dual JAK3/TEC inhibitor that blocks JAK3 signaling, resulting in the production of fewer cytokines and less inflammation, thereby allowing hair regeneration.

When purchasing and using ritexitinib, you should strictly abide by the doctor's prescription and medication instructions to ensure medication safety.