阿布昔替尼片的用药指南

Abxitinib tablets are a new type of JAK1 inhibitor that have shown significant efficacy in the treatment of moderate to severe atopic dermatitis. This article will introduce in detail the standardized use of this drug, possible side effects, and medication precautions for special groups to help patients use this drug correctly.

Medication Guide for Abxitinib Tablets

Correct use is crucial to the therapeutic effect. This drug needs to be strictly followed by the doctor's instructions and taken according to the prescribed dosage and method to achieve the best effect.

Standard dosage and adjustment

The conventional starting dose for adults is 100 mg once a day, and it is recommended to take it at a fixed time. If the effect is insufficient, it can be increased to 200 mg once a day after evaluation by a doctor. For patients under the age of 65 who need rapid relief of symptoms, consider starting with 200 mg and reducing to 100 mg for maintenance after 12 weeks.

How to take the medicine and precautions

The tablet should be swallowed whole with water and should not be crushed or chewed. It can be taken with food or alone, but the taking time must be consistent every day. If you miss a dose, you should decide whether to take it again according to the time to avoid double dose. Regular laboratory tests are required during treatment.

Evaluation and adjustment of treatment course

The treatment effect needs to be evaluated after 12 weeks of medication. If there is no obvious improvement, discontinuation of the medication should be considered. Patients with partial responses may experience further improvement with continued treatment. The dose should be adjusted according to individual response and the lowest effective dose should be used to maintain therapeutic effect.

Standardized medication methods combined with regular evaluation can help patients obtain the best therapeutic effect while reducing the risk of adverse reactions.

Side effects of Abxitinib Tablets

While Abxitinib Tablets exerts its therapeutic effect, it may cause a series of adverse reactions. Understanding these reactions will help to take timely countermeasures.

Common adverse reactions

At the 100mg dose, patients may experience symptoms such as nasopharyngitis, nausea, and headache. Some patients may experience reactions such as herpes simplex, elevated blood creatine phosphokinase, and dizziness. These symptoms are usually mild and can be tolerated by most.

Dose-related adverse reactions

When the dose is increased to 200 mg, more obvious adverse reactions may occur, including upper abdominal pain, abdominal discomfort, herpes zoster, and thrombocytopenia. The data showed that the incidence of adverse reactions was generally higher in the high-dose group.

Serious adverse reaction warning

Be alert to potential risks such as serious infection, thrombosis, and malignant tumors. You should seek medical attention immediately if you develop symptoms such as fever, difficulty breathing, abnormal bleeding or swelling. During treatment, live vaccines should be avoided and sun protection should be used.

Understanding the adverse reactions that may be caused by drugs can help patients detect abnormalities in time and take appropriate measures to ensure drug safety.

Usage of Absitinib Tablets for Special Populations

Different groups of people need to pay special attention to dose adjustment when using Absitinib Tablets to reduce the risk of special medication.

Using the drug in elderly patients

Elderly patients over 65 years old should use it with caution. Clinical data show that elderly patients are more likely to experience adverse reactions such as thrombocytopenia and herpes zoster. It is recommended to start with a low dose, strengthen monitoring, and adjust the treatment plan promptly if abnormalities occur.

Patients with hepatic and renal insufficiency

Patients with moderate renal impairment need to use it at a reduced dosage, and patients with severe renal impairment are not recommended to use it. No dose adjustment is usually required in patients with mild or moderate hepatic impairment, but use should be avoided in patients with severe hepatic impairment. Relevant indicators need to be monitored regularly during treatment.

Pregnant and lactating women

Pregnant and lactating women should use it with special caution. Existing data are insufficient to assess its safety to the fetus, and lactating women should suspend breastfeeding during treatment. Women of childbearing potential should be aware of the possible effects of medications on their fertility.

When using Abxitinib tablets for special groups, the treatment plan should be adjusted according to individual conditions and adverse reactions should be closely monitored.