阿布昔替尼片的副作用如何缓解

Abxitinib tablets are a highly selective JAK1 inhibitor developed by Pfizer of the United States. It is mainly used to treat moderate to severe atopic dermatitis (AD). Some side effects may occur in clinical application. This article will introduce the common side effects of this drug, relief methods, and medication guidelines to help patients better cope with problems that may arise during treatment.

Side effects of Abxitinib tablets

A variety of adverse reactions may occur during treatment. The incidence of these reactions is closely related to the dosage. Understanding these side effects will help patients discover and take appropriate measures in time.

Common mild side effects

At the 100mg dose, patients may experience symptoms such as nasopharyngitis, nausea, and headache. Some patients may also experience reactions such as herpes simplex, elevated blood creatine phosphokinase, dizziness, and urinary tract infection. These symptoms are usually mild and tolerated by most patients.

Dose-related side effects

When the dose is increased to 200 mg or higher, in addition to the above symptoms, patients may experience more obvious adverse reactions such as upper abdominal pain, abdominal discomfort, herpes zoster, and thrombocytopenia. Data showed that the incidence of adverse reactions in the high-dose group was generally higher than that in the low-dose group.

Abxitinib tablets have a wide spectrum of side effects, ranging from mild discomfort to more severe reactions, which require the joint attention of patients and medical staff.

How to alleviate the side effects of Abxitinib tablets

It is crucial to take appropriate mitigation measures for various adverse reactions that may be caused by Abxitinib tablets. Reasonable coping strategies can reduce patient discomfort and ensure the continuity of treatment.

Relief of gastrointestinal reactions

For gastrointestinal reactions such as nausea and vomiting, it is recommended that patients eat small amounts in portions and avoid taking medication on an empty stomach. Antiemetic drugs can be used under the guidance of a doctor when necessary. Staying adequately hydrated can also help relieve symptoms.

Infection Prevention and Management

Since this drug may increase the risk of infection, patients should strengthen personal hygiene and avoid contact with sources of infection during medication. When symptoms of infection appear, you should seek medical treatment promptly. If necessary, suspend medication and perform anti-infective treatment. Vaccination should be completed before medication.

Care for skin reactions

For skin problems such as acne and contact dermatitis, it is recommended to use mild skin care products and avoid irritating substances. If shingles develops, you should seek immediate medical attention. Treatment may need to be interrupted until symptoms resolve.

With targeted mitigation measures, most side effects can be effectively controlled, allowing patients to continue treatment.

Absitinib Tablets Medication Guide

Correct use of Abxitinib Tablets is the key to reducing side effects. Following standardized medication guidelines can maximize the effect of the drug and reduce the risk of adverse reactions.

Principles of dose adjustment

The conventional starting dose is 100 mg once a day, which can be increased to 200 mg when the efficacy is insufficient. For special groups such as elderly patients or those with liver and kidney dysfunction, the dose needs to be adjusted according to specific conditions. Patients with poor CYP2C19 metabolizers should start with 50 mg.

Medicine time and method

It is recommended to take the medicine at a fixed time every day, which can be taken with food or alone. Tablets should be swallowed whole and not chewed or crushed. If you miss a dose, you should decide whether to take it again according to the time to avoid double dose.

Monitoring and follow-up

During treatment, blood routine, liver and kidney function and other indicators need to be monitored regularly. Adverse reactions should be closely observed in the first 4 weeks, and then the frequency of monitoring should be adjusted according to the situation. If serious adverse reactions occur, timely medical evaluation should be sought.

Standardized medication methods combined with regular monitoring can help patients use Abxitinib tablets safely and effectively to achieve therapeutic effects.