迪高替尼软膏的适应症

Digotinib ointment is a new type of topical JAK inhibitor, mainly used to treat mild to moderate atopic dermatitis in adults and children. It regulates immune system function by inhibiting the activity of the Janus kinase (JAK) family, thereby alleviating skin inflammation and itching symptoms. Digotinib ointment has been approved for marketing in Japan, but has not yet been officially introduced in China. This article will introduce its indications, efficacy and effects, as well as contraindications in detail to help readers fully understand the clinical application of this drug.

Indications of Digotinib Ointment

The main indication is atopic dermatitis, which is a common chronic inflammatory skin disease characterized by dry skin, itching and erythema. The drug is suitable for adult patients aged 16 years and above, and can also be used for the treatment of pediatric patients aged 2 years and above.

Treatment of atopic dermatitis in adults

For adult patients, it is recommended to use a 0.5% concentration preparation of Digotinib ointment and apply it to the affected area twice a day. The drug can effectively reduce inflammation and relieve itching and skin damage. Clinical studies have shown that patients' symptoms can be significantly improved after 4 weeks of continuous use.

Treatment of atopic dermatitis in children

For pediatric patients over 2 years old and under 16 years old, it is recommended to use a preparation with a concentration of 0.25%. If the symptoms are severe, you can switch to 0.5% preparation under the guidance of a doctor, but the dosage needs to be strictly controlled. The dosage for infants and young children (over 6 months to under 2 years old) needs to be further reduced to ensure safety.

Digotinib ointment provides an effective topical treatment option for patients with atopic dermatitis, especially those who have responded poorly to conventional treatments.

Efficacy and role of Digotinib Ointment

Digotinib Ointment plays a therapeutic role by inhibiting the activity of JAK kinase and regulating the excessive response of the immune system. Its topical application can act directly on the affected area, reducing the risk of systemic side effects.

Anti-inflammatory effect

Digotinib ointment can inhibit the release of inflammatory factors and reduce skin redness, swelling and itching. Its mechanism of action is similar to that of systemic JAK inhibitors, but because it is administered locally, it is less absorbed throughout the body and is safer.

Improve skin barrier function

The skin barrier function of patients with atopic dermatitis is usually damaged. Digotinib ointment can not only relieve inflammation, but also indirectly promote the repair of skin barrier by regulating immune response, reducing water loss and the impact of external stimulation.

The dual action of Digotinib Ointment makes it ideal for the treatment of atopic dermatitis, especially for patients requiring long-term management.

Contraindications of Digotinib Ointment

Although Digotinib Ointment is excellent in treating atopic dermatitis, there are still some contraindications and precautions that patients and doctors should pay attention to.

Topical contraindications

Digotinib ointment is prohibited from being used on mucous membranes, ulcers or obviously damaged skin areas. The skin barrier function in these areas is compromised, and medications may cause irritation or worsen symptoms. In case of accidental contact with eyes, rinse immediately with water.

Contraindications for special groups

Pregnant women, lactating women and patients with liver and kidney dysfunction should use with caution. Animal experiments have shown that high-dose digotinib may cause harm to the fetus, so pregnant women should only use it when the benefits outweigh the risks. Breastfeeding women need to weigh the pros and cons of treatment versus breastfeeding.

Understanding the contraindications of Digotinib Ointment can help avoid unnecessary risks and reduce drug side effects.