克立硼罗软膏的作用与功效

Criborole ointment is a new type of non-steroidal external phosphodiesterase-4 (PDE-4) inhibitor, which plays an important role in the treatment of inflammatory skin diseases such as atopic dermatitis. Understanding its pharmacological effects, clinical efficacy and correct usage is of great significance for patients to obtain good therapeutic effects.

The functions and efficacy of Criborole Ointment

Through its unique anti-inflammatory mechanism, it can effectively relieve the symptoms of skin inflammation and improve the quality of life of patients.

Mechanism of action

Crisaborole reduces the production of pro-inflammatory cytokines and increases the release of anti-inflammatory mediators by selectively inhibiting phosphodiesterase-4 (PDE-4). This effect reduces skin inflammation and relieves itching and redness.

Pharmacological characteristics

Compared with other topical anti-inflammatory drugs, criborole has better skin permeability and local tolerance. Its unique borate ester structure allows it to effectively penetrate the stratum corneum of the skin and exert an anti-inflammatory effect at the lesion site.

Scope of Indications

It is mainly used for the treatment of mild to moderate atopic dermatitis in children and adults aged 2 years and above. It is especially suitable for patients who are intolerant to steroid drugs or require long-term treatment.

After understanding the mechanism of drug action, its clinical therapeutic effect is the issue that patients are most concerned about.

The efficacy of criborole ointment

Clinical studies have confirmed that criborole ointment has significant efficacy in the treatment of atopic dermatitis.

Improvement of symptoms

Most patients can observe relief of itching and subsidence of erythema within 1-2 weeks after taking the drug. After 4 weeks of continuous use, the area and severity of skin lesions were significantly improved in about half of the patients.

Long-term control

As a non-hormonal drug, criborole is suitable for long-term use to maintain its efficacy. Studies have shown that continued use can extend the remission period and reduce the recurrence of the disease.

Safety advantages

Compared with topical glucocorticoids, criborole does not cause adverse reactions such as skin atrophy and telangiectasia. It is safe for long-term use and is especially suitable for the face and areas with thin and tender skin.

Mastering the correct medication method is the key to ensuring efficacy and safety.

Precautions for use of criborole ointment

The use of criborole ointment requires specific medication methods and precautions.

Anaphylaxis

Allergic reactions, including contact urticaria, may occur in treated patients. Hypersensitivity reactions should be suspected if severe itching, swelling, and erythema occur at or distal to the application site. If signs and symptoms of allergy occur, discontinue use immediately and initiate appropriate treatment.

Correct usage

Apply a thin layer to the affected area twice a day. Clean and dry skin before use. Avoid contact with eyes, mouth and other mucous membranes. Wash hands after applying medication unless hands are treated.

Usage in special groups

The safety of children under 2 years of age has not been established. Pregnant women need to weigh the pros and cons when using it. Breastfeeding women should avoid use on the breast area.

Criboral ointment is a prescription drug and must be used strictly in accordance with the doctor's instructions. Patients should return for regular follow-up visits and report their medication reactions to the doctor in a timely manner.