鲁索替尼乳膏(Ruxolitinib cream)导致的不良反应怎么治疗

Introduction: Ruxolitinib Cream (Ruxolitinib cream) has demonstrated significant clinical efficacy in the treatment of atopic dermatitis and non-segmental vitiligo. But like most drugs, there may be a range of adverse reactions associated with their use. In response to these adverse reactions, timely and effective mitigation measures are crucial to ensure patient medication safety and improve quality of life.

Methods for alleviating adverse reactions in patients with atopic dermatitis

Nasopharyngitis: Use normal saline or mild nasal spray to clean the nasal cavity regularly and keep the nasal cavity moist, which can help relieve the symptoms of nasopharyngitis. Reduce exposure to allergens and irritating substances, such as smoke, dust, etc., to reduce nasopharyngeal discomfort.

Diarrhea: During diarrhea, the body is prone to dehydration, so you need to drink an appropriate amount of warm water or light salt water to replenish the water and electrolytes lost in the body. Choose light, easy-to-digest foods, such as rice porridge, noodles, etc., and avoid greasy, cold, and irritating foods to reduce the burden on the gastrointestinal tract.

Bronchitis, ear infection, tonsillitis: These infection symptoms may require diagnosis and treatment by a professional doctor. Patients should seek medical treatment as soon as possible and follow the doctor's instructions. Pay attention to personal hygiene and wash hands frequently to avoid cross infection.

Increased eosinophil count, urticaria, and folliculitis: For cases with increased eosinophil count, blood routine needs to be monitored regularly and the treatment plan adjusted if necessary. Urticaria and folliculitis can be relieved with topical use of mild anti-inflammatory and anti-allergic ointments, but care should be taken to avoid simultaneous use.

Rhinorrhoea: Regularly clean the nasal cavity with saline or a mild nasal spray to remove secretions and allergens in the nasal cavity and reduce the symptoms of rhinorrhea.

Methods to alleviate adverse reactions in patients with non-segmental vitiligo

Acne at the application site: Keep the treatment area clean and dry, and avoid using too greasy skin care products or cosmetics. Under the guidance of a doctor, use a mild anti-inflammatory ointment topically for relief, but be careful to avoid using it at the same time as ruxolitinib cream.

Itching at the application site: Use a cold towel or ice pack to apply a cold compress to the itchy area to help relieve the itching. Apply an appropriate amount of moisturizing product to keep your skin hydrated to relieve itching symptoms.

Headache: Ensure adequate rest and sleep time to avoid overexertion. Gently massaging your temples or neck muscles can help relieve headache symptoms.

Urinary tract infection: Increase water intake, promote urination, and help flush bacteria from the urinary tract. If symptoms persist or worsen, you should seek medical treatment promptly and follow the doctor's instructions for antibacterial treatment.

Erythema and fever at the application site: For erythema at the application site, you can use a cold towel to apply cold compress to relieve symptoms. If you are accompanied by fever symptoms, you can take an appropriate amount of over-the-counter antipyretics for relief, but you need to pay attention to monitoring changes in body temperature to avoid excessive use.