奥拉迪约是什么药物？治疗什么疾病？

Oradejo is a plasma kallikrein inhibitor that binds to plasma kallikrein and inhibits its proteolytic activity. Plasma kallikrein is a protease that cleaves high molecular weight kininogen (HMWK) to produce cleaved HMWK (cHMWK) and bradykinin, a potent vasodilator that increases vascular permeability, leading to the swelling and pain associated with HAE. Let’s learn more about what kind of medicine it is today? What disease is treated?

Oradejo is a plasma kallikrein inhibitor indicated for the prophylaxis of hereditary angioedema (HAE) attacks in adults and children 12 years of age and older. Oradejo is the first and only oral therapy specifically designed to prevent the onset of hereditary angioedema (HAE) in adult and pediatric patients 12 years and older. Taking one Oradejo capsule daily may prevent HAE attacks by reducing plasma kallikrein activity.

The U.S. Food and Drug Administration (FDA) has approved oral, once-daily Oradejo prophylaxis to prevent the onset of hereditary angioedema (HAE) in adults and children 12 years of age and older.

In the pivotal Phase 3 APeX-2 trial, Oladiyo significantly reduced seizures at 24 weeks, and this reduction was sustained through 48 weeks. HAE patients who completed 48 weeks of treatment (150 mg) experienced a reduction in HAE attack rates, from an average of 2.9 attacks per month at baseline to 1.0 attacks per month after 48 weeks of treatment. In the long-term open-label APeX-S trial, patients who completed 48 weeks (150 mg) of treatment had an average exacerbation rate of 0.8 attacks per month.

Recommended dose of Oradejo: Take one capsule (150 mg) once daily with food. During the treatment period, patients should not increase or decrease the dosage of drugs without authorization. Increasing the dosage of drugs will not make the condition improve quickly, but will lead to adverse reactions. Therefore, patients should strictly follow the doctor's diagnosis and treatment recommendations and should not use drugs without authorization.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.